PMID: 9444352Jan 28, 1998Paper

Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease

Acta Neuropathologica
T A BayerG Multhaup

Abstract

The Alzheimer's disease (AD) beta-amyloid precursor protein (APP) and the amyloid precursor-like protein 1 (APLP1) and 2 (APLP2) are members of a super-family of proteins that appear functionally related. Although APLPs are highly homologous to APP in the N- and C-terminal domains, they lack the beta A4/amyloid peptide, i.e., the main constituent of neuritic plaques in AD. To assess a potential role of APLP1 in AD, we have determined its immunohistochemical distribution in human hippocampal formation, a structure which is strongly affected in AD, and compared it with APP immunoreactivity. There was a considerable overlap of APP and APLP1 regional expression patterns. Significant APLP1 immunoreactivity was observed in neuritic plaques. Large pyramidal neurons of the subiculum showed an accumulation of APLP1 protein in their dendritic compartment. Some astrocytes elicited perinuclear APLP1 staining, but this was observed in both AD and control brains. These findings raise the possibility that APLP1 may contribute to the pathogenesis of AD-associated neurodegeneration.

Citations

Mar 6, 2015·Apoptosis : an International Journal on Programmed Cell Death·Xingjun WangLei Xue
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Daniela DiehlStefan Bauersachs
Dec 14, 2005·The Journal of Biological Chemistry·Stephanie NeumannStefan F Lichtenthaler
Apr 12, 2007·Expert Review of Proteomics·Simon LovestoneMalcolm Ward
May 24, 2014·The Journal of Biological Chemistry·Magnus C MayerGerhard Multhaup
Aug 16, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Bryant LimEleftherios P Diamandis
Jan 8, 2009·Journal of Cell Science·Daniela KadenGerd Multhaup
Aug 30, 2021·Molecular Neurodegeneration·M Mahafuzur Rahman, Christofer Lendel

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