PMID: 9181045Jan 1, 1997Paper

Amyloid precursor protein, copper and Alzheimer's disease

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
G Multhaup

Abstract

Although a consensus that Alzheimer's disease (AD) is a single disease has not yet been reached, the involvement of the amyloid precursor protein (APP) and beta A4 (A beta) in the pathologic changes advances our understanding of the underlying molecular alterations. Increasing evidence implicates oxidative stress in the neurodegenerative process of AD. This hypothesis is based on the toxicity of beta A4 in cell cultures, and the findings that aggregation of beta A4 can be induced by metal-catalyzed oxidation and that free oxygen radicals might be involved in APP metabolism. Another neurological disorder, familial amyotrophic lateral sclerosis (FALS), supports our view that AD and FALS might be linked through a common mechanism. In FALS, SOD-Cu(I) complexes are affected by hydrogen peroxide and free radicals are produced. In AD, the reduction of Cu(II) to Cu(I) by APP involves an electron-transfer reaction and could also lead to a production of hydroxyl radicals. Thus, copper-mediated toxicity of APP-Cu(II)/(I) complexes may contribute to neurodegeneration in AD.

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Jan 1, 1975·Annual Review of Biochemistry·I Fridovich
Jul 27, 1992·FEBS Letters·B Halliwell, J M Gutteridge
Aug 28, 1992·Science·E R Stadtman
May 15, 1992·Thrombosis Research·Y KomiyamaK Murata
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D SmithW R Markesbery
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Jun 1, 1989·The New England Journal of Medicine·B RumbleC L Masters
Oct 26, 1989·The New England Journal of Medicine·G Heinrich
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C J EpsteinY Groner
Oct 15, 1983·Archives of Biochemistry and Biophysics·M A Takahashi, K Asada
Jun 30, 1995·Science·D J Fitzgerald
Jul 15, 1993·European Journal of Biochemistry·H Sies
Apr 1, 1995·Trends in Neurosciences·M A SmithG Perry
Jul 25, 1994·FEBS Letters·L HesseG Multhaup
Oct 1, 1993·Journal of Neurochemistry·J BusciglioB A Yankner

❮ Previous
Next ❯

Citations

Oct 31, 2002·Human Psychopharmacology·Kurt Heininger
Feb 18, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Fangyu PengOtto Muzik
Oct 24, 2002·Neurobiology of Aging·Carl W CotmanNorton W Milgram
Jun 25, 2003·Toxicology·Lisa M Gaetke, Ching Kuang Chow
Dec 4, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Haim Tapiero, Kenneth D Tew
Nov 24, 1999·Neurotoxicology and Teratology·C L Kwik-UribeC L Keen
Mar 10, 2001·The Biochemical Journal·T GoswamiJ M Blackwell
Dec 12, 2001·Cellular Microbiology·J M BlackwellM Ibrahim
Jul 19, 2002·Journal of Neurochemistry·E HeadC W Cotman
May 18, 1999·Current Opinion in Oncology·L L Herscher, J Cook
Aug 21, 2002·Anti-cancer Drugs·Walter J LoosAlex Sparreboom
May 20, 2000·Annals of the New York Academy of Sciences·R P FriedlandG Perry
May 29, 2002·European Journal of Clinical Nutrition·K SchümannH K Biesalski
Jan 18, 2007·Journal of Computational Chemistry·Hsiu-Feng LuS H Lin
Jan 15, 2010·Neuropathology and Applied Neurobiology·R BoleaJ J Badiola
Mar 11, 2004·Journal of Neurochemistry·Shinsuke MatsuzakiMasaya Tohyama
Sep 10, 2014·Archives of Toxicology·Lisa M GaetkeChing K Chow
Feb 26, 2013·Magnetic Resonance in Chemistry : MRC·Abdul-Hamid M EmwasHarbi T Al-Masri
Oct 19, 2000·Journal of the American Geriatrics Society·C BerrA Alpérovitch
Apr 25, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Rawiah A AlsiaryAbdul-Hamid Emwas
Feb 19, 2000·The American Journal of Clinical Nutrition·Y Christen
Jul 30, 1999·Biochemical and Biophysical Research Communications·J CamakarisJ F Mercer
Feb 8, 2000·Brain Research·M S HorningP Q Trombley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.