Amyloid proximal tubulopathy: a novel form of light chain proximal tubulopathy

Clinical Kidney Journal
Christopher P LarsenPatrick D Walker

Abstract

Light chain proximal tubulopathy is a paraproteinemic-related kidney disease most commonly seen in patients with a plasma cell dyscrasia. The classic description is that of proximal tubules with kappa-restricted intracytoplasmic crystals in a patient with a clinical Fanconi's syndrome. Recently, other variants of light chain proximal tubulopathy have been described including those without crystal formation. We expand the morphologic spectrum in this report of a patient who presented with acute renal failure, proteinuria and hematuria. Biopsy revealed proximal tubulopathy in which the proximal tubules show intracytoplasmic amyloid formation. This is the first description, to our knowledge, of amyloid proximal tubulopathy.

References

Dec 1, 1987·Kidney International·P W SandersJ H Galla
Aug 4, 2006·Journal of the American Society of Nephrology : JASN·Stephen M Korbet, Melvin M Schwartz
Jul 5, 2007·Kidney International·Z El-ZoghbyS Sethi
Sep 11, 2007·Archives of Pathology & Laboratory Medicine·Umesh KapurMaria M Picken
Oct 28, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sekiko TanedaHideaki Oda
Jun 30, 2009·The American Journal of Surgical Pathology·Hanna von HuttenChristoph Röcken
Jun 28, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher P LarsenPatrick D Walker

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Citations

Oct 21, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jean-Baptiste GibierDavid Buob
Jan 15, 2020·Virchows Archiv : an International Journal of Pathology·Shojiro IchimataNaoki Nishida
Sep 24, 2016·Blood Cancer Journal·I-A IliutaP Isenring
Aug 5, 2021·Journal of Medical Case Reports·Wael Mostafa Hamza, Ahmed Mohammed AlEssa

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Methods Mentioned

BETA
biopsy

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