Amyloid Signaling in Filamentous Fungi and Bacteria.

Annual Review of Microbiology
Sven J Saupe

Abstract

Amyloids are implicated in many protein misfolding diseases. Amyloid folds, however, also display a range of functional roles particularly in the microbial world. The templating ability of these folds endows them with specific properties allowing their self-propagation and protein-to-protein transmission in vivo. This property, the prion principle, is exploited by specific signaling pathways that use transmission of the amyloid fold as a way to convey information from a receptor to an effector protein. I describe here amyloid signaling pathways involving fungal nucleotide binding and oligomerization domain (NOD)-like receptors that were found to control nonself recognition and programmed cell death processes. Studies on these fungal amyloid signaling motifs stem from the characterization of the fungal [Het-s] prion protein and have led to the identification in fungi but also in multicellular bacteria of several distinct families of signaling motifs, one of which is related to RHIM [receptor-interacting protein (RIP) homotypic interaction motif], an amyloid motif regulating mammalian necroptosis.

References

Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·V CoustouJ Begueret
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·R B Wickner
Apr 20, 2002·Cell Death and Differentiation·E V Koonin, L Aravind
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Marie-Lise MaddeleinSven J Saupe
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Henk J P DalstraRolf F Hoekstra
Aug 19, 2003·Genes & Development·B Tibor Roberts, Reed B Wickner
Mar 24, 2004·Genes & Development·Reed B WicknerAndreas Brachmann
Jun 10, 2005·Nature·Christiane RitterRoland Riek
Nov 23, 2005·PLoS Biology·Douglas M FowlerJeffery W Kelly
Jul 1, 2006·Nature·Motomasa TanakaJonathan S Weissman
Dec 28, 2006·Advances in Protein Chemistry·Andrey V Kajava, Alasdair C Steven
Mar 16, 2007·PloS One·Mathieu PaolettiCorinne Clavé
Mar 21, 2009·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·C P J Maury
Jul 23, 2009·Science Signaling·Matthew P BadtkeMatthew R Chapman
Oct 2, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mathieu Paoletti, Sven J Saupe
Jul 14, 2010·Molecular Cell·Jason GreenwaldRoland Riek
Sep 11, 2010·Journal of the American Chemical Society·Hélène Van MelckebekeBeat H Meier
Nov 18, 2010·Nature Reviews. Molecular Cell Biology·Mick F Tuite, Tricia R Serio
Feb 22, 2011·Seminars in Cell & Developmental Biology·Sven J Saupe
Mar 23, 2011·Cold Spring Harbor Perspectives in Biology·David W Colby, Stanley B Prusiner
Jul 6, 2011·Molecular Cell·Timo Eichner, Sheena E Radford
Dec 27, 2011·Trends in Microbiology·Luz P BlancoMatthew R Chapman
Mar 20, 2012·Cell·David Eisenberg, Mathias Jucker
May 1, 2012·Journal of Molecular Biology·Jason Greenwald, Roland Riek
Jun 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alfons J M DebetsSven J Saupe
Dec 5, 2012·Prion·Karen H Ashe, Adriano Aguzzi
Jan 10, 2013·PLoS Biology·Carolin SeuringRoland Riek
Jan 10, 2013·PLoS Biology·Douglas M Fowler, Jeffery W Kelly
Mar 15, 2013·Trends in Cell Biology·Gregory A Newby, Susan Lindquist
Sep 10, 2013·Immunity·James M MurphyWarren S Alexander
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·William Wan, Gerald Stubbs

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Citations

Jan 19, 2021·Biophysical Journal·Alejandro Rodríguez GamaRandal Halfmann
Jan 12, 2021·Trends in Biochemical Sciences·Shon A LevkovichDana Laor Bar-Yosef
Feb 13, 2021·Prion·Asen Daskalov, Sven J Saupe

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