Jun 1, 1978

Amyloid transfer from a syngenous transplant of amyloid spleen in intact and amyloid mice

Biulleten' eksperimental'noĭ biologii i meditsiny
V V SuraA Iu Gritsman

Abstract

Investigations were carried out on male CBA mice with casein-induced amyloidosis. Fragments of spleens from the amyloid and intact donors were transplanted simultaneously to the opposite kidney poles, subcapsularly, to the intact and amyloid recipients. Amyloid deposits were found in 40 per cent of intact recipients both in their own spleens and in the grafts from intact donors. In amyloid recipients amyloid deposits developed in the grafts from intact donors only in 5 per cent of the animals (observation periods from 5 days to 6 months after the transplantation). It is amyloidogenic cells migration and the depression of this mechanism in amyloid mice.

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Mentioned in this Paper

Mice, Inbred CBA
Amyloidosis
Spleen
Plaque, Amyloid
Amyloid Neuropathies
Transplantation, Homologous

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