Amyloid tumor: a clinical and cytomorphologic study

Diagnostic Cytopathology
Sunati SahooRichard M DeMay

Abstract

We describe the cytologic findings and clinical presentation of three unusual cases of amyloid tumor. Two of our patients had low-grade lymphoid malignancies and the third insulin-dependent diabetes mellitus. In no cases was amyloid suspected as the cause of mass lesion. Two of our cases presented with superficial soft tissue mass and the third with right breast masses and bilateral axillary lymph node enlargement. Air-dried slides from all aspirated cases were stained with Diff-Quik for specimen adequacy evaluation. The remaining fixed slides were stained with Papanicolaou stain. Amyloid appeared as dark-blue to purple clumps of acellular material on Diff-Quik stain, accompanied with chronic inflammatory cell infiltrates and multinucleated giant cells, simulating granulomatous inflammation. Papanicolaou stain demonstrated cyanophilic to orangophilic acellular material. Amyloid was suspected and subsequently confirmed by Congo red stain.

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Citations

Dec 4, 2008·Skeletal Radiology·Aditya V MaheshwariH Thomas Temple
Apr 7, 2007·The American Journal of Dermatopathology·Sylvia PasternakNoreen Walsh
Mar 28, 2008·Southern Medical Journal·Ediz TutarYavuz Pehlivan
Aug 18, 2009·Human Pathology·Saniye YumluChristoph Röcken
Dec 15, 2006·European Journal of Radiology·Alexandra AthanasiouCorinne Balleyguier
Mar 1, 2012·Diagnostic Cytopathology·Camille T ElkinsPaul E Wakely
Feb 1, 2014·Biochimica Et Biophysica Acta·Ajay K MahalkaPaavo K J Kinnunen
Apr 16, 2016·Drug and Chemical Toxicology·Raheleh KheirbakhshAzadeh Ebrahim-Habibi
Nov 26, 2019·Diagnostic Cytopathology·Garima RakhejaSarabmeet S Lehl
Feb 12, 2010·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Natalie M WiegelReinhold P Linke
Feb 21, 2019·Surgical Case Reports·Makiko MoriHiroji Iwata
Jul 11, 2014·Experimental and Therapeutic Medicine·Maryam ChinisazAhmad-Reza Dehpour
Oct 27, 2004·Archives of Pathology & Laboratory Medicine·Richard L BardinKim R Geisinger

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