Amyloidogenic protein-membrane interactions: mechanistic insight from model systems

Angewandte Chemie
Sara M Butterfield, Hilal A Lashuel

Abstract

The toxicity of amyloid-forming proteins is correlated with their interactions with cell membranes. Binding events between amyloidogenic proteins and membranes result in mutually disruptive structural perturbations, which are associated with toxicity. Membrane surfaces promote the conversion of amyloid-forming proteins into toxic aggregates, and amyloidogenic proteins, in turn, compromise the structural integrity of the cell membrane. Recent studies with artificial model membranes have highlighted the striking resemblance of the mechanisms of membrane permeabilization of amyloid-forming proteins to those of pore-forming toxins and antimicrobial peptides.

References

Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P WestermarkK H Johnson
Jun 18, 1985·Biochemistry·H EllensF C Szoka
Feb 18, 1972·Science·S J Singer, G L Nicolson
Jan 1, 1971·Journal of Biochemistry·Y TamaiM Satake
Oct 1, 1981·The Journal of Cell Biology·R FüssleH J Wellensiek
Jul 7, 1981·Biochemistry·D K StruckR E Pagano
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N ArispeE Rojas
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N ArispeH B Pollard
Jan 26, 1996·The Journal of Biological Chemistry·T A MirzabekovB L Kagan
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·N ArispeE Rojas
Oct 1, 1995·Cellular and Molecular Neurobiology·H B PollardE Rojas
Nov 15, 1996·The Journal of Biological Chemistry·T PillotL Lins
Mar 1, 1997·Protein Science : a Publication of the Protein Society·T G Fletcher, D A Keire
Jun 5, 1997·Nature·B A CornellR J Pace
Aug 28, 1997·Nature·M G SpillantiniM Goedert
Jul 17, 1998·Journal of the Neurological Sciences·M A LovellW R Markesbery
Sep 12, 1998·Biochimica Et Biophysica Acta·M A CooperD H Williams
Nov 18, 1998·Current Opinion in Structural Biology·W L HubbellM A Lietzow
Jul 29, 2000·Biochemistry·H W Huang
Aug 10, 2000·Biochimica Et Biophysica Acta·A FischerP L Luisi
Sep 26, 2000·Journal of Neuroscience Research·J I Kourie, A Culverson
Apr 5, 2001·Journal of Molecular Biology·D EliezerG Browne
Jun 12, 2001·Analytical Biochemistry·J M Rausch, W C Wimley
Aug 18, 2001·Biophysical Journal·L YangH W Huang
Oct 10, 2001·Journal of Neuroscience Research·J I KourieC L Henry
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H LinR Lal

❮ Previous
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Citations

Jun 29, 2013·Journal of Fluorescence·Olga K KutsenkoAleksey Vasilev
Sep 24, 2013·Accounts of Chemical Research·Yongju KimMyongsoo Lee
Jun 21, 2011·Biochemistry·Keisuke IkedaKatsumi Matsuzaki
May 9, 2012·Biochemistry·Gai LiuNoel D Lazo
Sep 14, 2012·Biochemistry·Michele F M SciaccaAyyalusamy Ramamoorthy
Mar 21, 2013·ACS Chemical Neuroscience·Coralie Di ScalaJacques Fantini
Jul 5, 2013·ACS Chemical Neuroscience·Erik HellstrandEmma Sparr
Oct 11, 2013·ACS Chemical Neuroscience·Marcos J Guerrero-MuñozRakez Kayed
Sep 7, 2013·ACS Chemical Neuroscience·Workalemahu M BerhanuUlrich H E Hansmann
Jan 31, 2013·Journal of the American Chemical Society·Seung-gu KangRuhong Zhou
Aug 10, 2013·Journal of the American Chemical Society·Johnny D PhamJames S Nowick
Jul 20, 2011·Physical Chemistry Chemical Physics : PCCP·Qiuming WangJie Zheng
Mar 16, 2013·Physical Chemistry Chemical Physics : PCCP·Xiang YuJie Zheng
Mar 22, 2013·Physical Chemistry Chemical Physics : PCCP·Kenji SasaharaKyoko Shinya
Apr 25, 2013·Nanoscale·Xingfei ZhouYi Zhang
Dec 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jung-Suk ChoiMi Hee Lim
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lilia MilanesiHelen R Saibil
Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Anupama LakshmananCharlotte A E Hauser
Nov 7, 2012·The Journal of Biological Chemistry·Katharina FlachMax Holzer
Dec 7, 2013·PloS One·Chiara FecchioPatrizia Polverino de Laureto
Jan 1, 2014·PloS One·Neha JainSamrat Mukhopadhyay
Jul 23, 2014·PloS One·Mira PolajnarEva Žerovnik
Feb 1, 2014·Physical Chemistry Chemical Physics : PCCP·Javed M KhanRizwan H Khan
Dec 4, 2013·The Journal of Physical Chemistry. B·Nathan A BernhardtUlrich H E Hansmann
Mar 29, 2014·Physical Chemistry Chemical Physics : PCCP·Masamune MoritaMasahiro Takagi
Feb 25, 2014·Trends in Pharmacological Sciences·Paolo ArosioTuomas P J Knowles
Nov 10, 2013·Advances in Colloid and Interface Science·Annalisa ReliniAlessandra Gliozzi
Dec 17, 2014·The Journal of Chemical Physics·Liming QiuMark W Vaughn
Jan 26, 2016·Biochimica Et Biophysica Acta·Chian Sing HoJianjun Pan
Mar 31, 2015·Biomolecules·Hazel L Roberts, David R Brown
Aug 25, 2015·FEBS Letters·Andreas van MaarschalkerweerdBente Vestergaard
May 16, 2015·Journal of Molecular Biology·Senthil T KumarMatthias Görlach
Dec 31, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Nadine SchwierzMartin Zacharias
Jan 22, 2015·Immunity·Sohini Mukherjee, Lora V Hooper
Jan 19, 2016·Molecular Neurobiology·Erica LanaHomira Behbahani

❮ Previous
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