Amyloidosis cardiomyopathy: update in the diagnosis and treatment of the most common types

Current Opinion in Cardiology
Jose Nativi-Nicolau, Mathew S Maurer

Abstract

The present article provides an update about the recent advances in the diagnosis and management of the most common types of cardiac amyloidosis, including light chain, wild-type transthyretin (ATTRwt), and mutant transthyretin (ATTRm). The document reviews the utility of diagnostic tools including innovative echocardiographic indices, magnetic resonance T1 mapping and measurement of extracellular volume, and the role and validation of bone scintigraphy for the noninvasive assessment of ATTR amyloidosis. It summarizes the data about therapies for light chain amyloidosis including bortezomib regimens and also novel disease modifying therapies for ATTR amyloidosis such as gene silencers, transthyretin stabilizers, and degraders of amyloid fibrils. The present review provides the readers with the necessary tools in order to recognize and diagnose cardiac amyloidosis early and introduces the recent advances in management that are improving the outcomes of a condition that was considered to be untreatable.

References

Jun 1, 1985·The American Journal of Cardiology·M A GertzR A Kyle
Jun 1, 1981·Circulation·A RubinowA S Cohen
Dec 1, 1961·Annals of Internal Medicine·J T CASSIDY
Mar 31, 2006·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Oct 29, 2009·FEBS Letters·Nelson FerreiraMaria Rosário Almeida
Feb 18, 2010·JACC. Cardiovascular Imaging·Imran S SyedMartha Grogan
Oct 19, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Shu-ichi IkedaJun Koyama
Nov 10, 2011·The Journal of Pathology·Jonathan K Watts, David R Corey
Nov 15, 2011·The American Journal of Cardiology·Federico PerfettoFrancesco Cappelli
May 4, 2012·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Laura ObiciGiampaolo Merlini
Jun 27, 2012·Haematologica·Andrew J CowanVaishali Sanchorawala
Jul 4, 2012·Congestive Heart Failure·Adam CastañoMathew S Maurer
Mar 19, 2013·JACC. Cardiovascular Imaging·Theodoros D KaramitsosJames C Moon
Mar 28, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Zhongwei ChengQuan Fang
May 15, 2013·Blood·Giampaolo MerliniGiovanni Palladini
Mar 14, 2014·Upsala Journal of Medical Sciences·Per WestermarkSvante Berg
Jul 12, 2014·Journal of the Neurological Sciences·N SuanprasertP J Dyck
Sep 6, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Akihiro YanagisawaHiroshi Mizuta
Sep 13, 2014·The American Journal of Cardiology·Nicole B CyrilleMathew S Maurer
Nov 27, 2014·Heart Failure Reviews·Walter NoordzijClaudio Rapezzi
Dec 17, 2014·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Amanda TendlerMathew S Maurer
Jan 19, 2015·Heart Failure Reviews·Rodney H Falk, C Cristina Quarta
Jul 1, 2015·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Daniel R JacobsonJoel N Buxbaum
Dec 18, 2015·Drug Design, Development and Therapy·Fabian Aus dem SiepenArnt V Kristen
Feb 10, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Morie A GertzMichaela Liedtke
Feb 18, 2016·Radiology·Erik B Schelbert, Daniel R Messroghli
May 5, 2016·Circulation·Julian D GillmorePhilip N Hawkins
Jul 9, 2016·Journal of the American College of Cardiology·Mathew S MaurerUNKNOWN THAOS Investigators
Sep 3, 2016·Journal of the American College of Cardiology·Martha GroganAngela Dispenzieri
Jan 4, 2017·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Jonas WixnerIntissar Anan
Apr 4, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Seitaro OdaYasuyuki Yamashita
Jun 13, 2017·European Heart Journal·Candida Cristina QuartaJulian D Gillmore

❮ Previous
Next ❯

Citations

Jun 2, 2020·Circulation·Michelle M KittlesonUNKNOWN American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology
Dec 18, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Carmela NappiAlberto Cuocolo
Dec 20, 2019·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Mónica InêsJoão Costa
Dec 4, 2019·Current Cardiology Reports·Aaron M WolfsonJignesh K Patel
Feb 23, 2019·Heart Failure Reviews·Angelos G RigopoulosMichel Noutsias
Aug 4, 2019·European Journal of Internal Medicine·Antonis S ManolisHelen Melita
Aug 2, 2019·Brain and Behavior·Morie A GertzTeresa Coelho
Sep 5, 2019·Circulation. Heart Failure·Mathew S MaurerGiampaolo Merlini
Jan 19, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·A YilmazN Frey
Dec 22, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Angela RussellNowell M Fine
Mar 10, 2021·The Annals of Pharmacotherapy·Jankhna D YadavJennifer Towle
Feb 26, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Monica AlcantaraVera Bril
Sep 7, 2021·Herz·Sophiko Erbel-KhurtsidzeArtur Lichtenberg
Jun 24, 2019·Cardiology·Theis Tønnessen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Amyloidosis

Cardiac amyloidosis is a myocardial disease characterized by extracellular amyloid infiltration throughout the heart. Discover the latest research on cardiac amyloidosis here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.