Amyotrophic Lateral Sclerosis and Metabolomics: Clinical Implication and Therapeutic Approach

Journal of Biomarkers
Alok KumarR L Singh

Abstract

Amyotrophic lateral sclerosis (ALS) is one of the most common motor neurodegenerative disorders, primarily affecting upper and lower motor neurons in the brain, brainstem, and spinal cord, resulting in paralysis due to muscle weakness and atrophy. The majority of patients die within 3-5 years of symptom onset as a consequence of respiratory failure. Due to relatively fast progression of the disease, early diagnosis is essential. Metabolomics offer a unique opportunity to understand the spatiotemporal metabolic crosstalks through the assessment of body fluids and tissue. So far, one of the most challenging issues related to ALS is to understand the variation of metabolites in body fluids and CNS with the progression of disease. In this paper we will review the changes in metabolic profile in response to disease progression condition and also see the therapeutic implication of various drugs in ALS patients.

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Citations

Jan 9, 2019·Frontiers in Neurology·Débora LanznasterHélène Blasco
Jul 17, 2015·Oxidative Medicine and Cellular Longevity·Ester TelloneSilvana Ficarra
Nov 17, 2020·Frontiers in Neuroscience·Giovanna MorelloSebastiano Cavallaro

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR
transgenic
biopsies
metabolomic profiling

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Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

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