PMID: 9558138Apr 29, 1998Paper

An abbreviated area-under-the-curve monitoring for tacrolimus in patients with liver transplants

Therapeutic Drug Monitoring
Y M Ku, D I Min

Abstract

This study aims to assess the predictability of individual tacrolimus (FK) concentrations at different time points for the area under the curve (AUC) and to find the best sampling time for the abbreviated AUC to predict the total body exposure of FK. A total of 23 FK blood concentration versus time profiles (11 blood samples per 12 hours) was studied in 12 stable patients with liver transplants at steady state. Each AUC was calculated by the trapezoidal rule, and the relationship between individual concentrations or abbreviated AUC and total AUC was determined by linear regression. The trough concentrations from the morning dose predict AUC better than the trough concentration from the evening dose (r2 = 0.71 for morning dose and r2 = 0.35 for evening dose). In the case of single drug concentration, the 4-hour concentration could predict the total AUC reasonably well (r2 = 0.73). From stepwise multiple regression, the abbreviated AUC at 1, 2.5, 6, and 9 hours could predict the total AUC most accurately (r2 = 0.99). This study shows that the four levels at 1, 2.5, 6, and 9 hours or 1, 4, and 12 hours as an abbreviated AUC is as good as a full pharmacokinetic study. Alternatively, 4-hour concentration is a good predictor of the t...Continue Reading

References

Apr 1, 1994·The Annals of Pharmacotherapy·M A Hooks
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Citations

Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Regine RagetteHeinz Jakob
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Vartan MardigyanMarcelo Cantarovich
Aug 15, 2002·Transplantation Proceedings·F BraunB Ringe
Dec 21, 2002·Transplantation Proceedings·T PisitkunK Tungsanga
Jul 9, 2002·Clinical Transplantation·Claudia R FelipeJosé O M Pestana
Dec 26, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Y SakamotoH Sato
Aug 8, 2013·Pharmacogenetics and Genomics·Julia M BarbarinoRuss B Altman
Jul 13, 2004·Clinical Pharmacokinetics·Christine E Staatz, Susan E Tett
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·S M Tsunoda, F T Aweeka
Aug 23, 2007·European Journal of Clinical Pharmacology·Robert A M Op den BuijschOtto Bekers
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Christiane KnoopMarc Estenne
Feb 5, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Dirk R J Kuypers
Sep 5, 2003·Journal of Clinical Pharmacology·Hitoshi TadaToshio Suzuki
Apr 26, 2008·Pediatric Transplantation·Joshua Y KausmanStephen D Marks
Feb 16, 2006·Journal of Clinical Pharmacy and Therapeutics·C DansirikulS E Tett
Dec 8, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·John M KovarikAlan Slade
Jan 28, 2010·Basic & Clinical Pharmacology & Toxicology·Radmila M Velickovic-RadovanovicTatjana Cvetkovic
Jun 17, 2006·Therapeutic Drug Monitoring·Lillian S L TingMary H H Ensom
Dec 1, 2004·Therapeutic Drug Monitoring·Chantaratsamon DansirikulSusan E Tett
May 8, 1999·British Journal of Clinical Pharmacology·A Johnston, D W Holt
Mar 26, 2003·Archives of Pathology & Laboratory Medicine·Bernard W SteeleUNKNOWN College of American Pathologists Study

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