An acetylation switch regulates SUMO-dependent protein interaction networks.

Molecular Cell
Rebecca UllmannStefan Muller

Abstract

The attachment of the SUMO modifier to proteins controls cellular signaling pathways through noncovalent binding to SUMO-interaction motifs (SIMs). Canonical SIMs contain a core of hydrophobic residues that bind to a hydrophobic pocket on SUMO. Negatively charged residues of SIMs frequently contribute to binding by interacting with a basic surface on SUMO. Here we define acetylation within this basic interface as a central mechanism for the control of SUMO-mediated interactions. The acetyl-mediated neutralization of basic charges on SUMO prevents binding to SIMs in PML, Daxx, and PIAS family members but does not affect the interaction between RanBP2 and SUMO. Acetylation is controlled by HDACs and attenuates SUMO- and PIAS-mediated gene silencing. Moreover, it affects the assembly of PML nuclear bodies and restrains the recruitment of the corepressor Daxx to these structures. This acetyl-dependent switch thus expands the regulatory repertoire of SUMO signaling and determines the selectivity and dynamics of SUMO-SIM interactions.

References

May 2, 2000·The Journal of Biological Chemistry·S MullerA Dejean
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Darja Schmidt, Stefan Müller
Jun 22, 2002·Molecular and Cellular Biology·Noora KotajaJorma J Palvimo
Dec 20, 2003·Cellular and Molecular Life Sciences : CMLS·D Schmidt, S Müller
Sep 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jing SongYuan Chen
Dec 21, 2004·Nature Structural & Molecular Biology·Michael H TathamRonald T Hay
May 5, 2005·Molecular and Cellular Biology·Sergey ChupretaJorge A Iñiguez-Lluhí
Jun 3, 2005·Nature·David Reverter, Christopher D Lima
Jun 17, 2005·Nature·Daichi BabaMasahiro Shirakawa
Mar 10, 2006·The Journal of Biological Chemistry·Christina-Maria HeckerIvan Dikic
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Adam RosendorffGrace Gill
Apr 13, 2006·The Journal of Biological Chemistry·Limin Gong, Edward T H Yeh
Apr 22, 2006·Journal of Molecular Biology·Daichi BabaMasahiro Shirakawa
Jul 11, 2006·Nature Reviews. Molecular Cell Biology·Bruce T SeetTony Pawson
Apr 5, 2007·Nature Protocols·Joel D NelsonKarol Bomsztyk
May 15, 2007·Trends in Biochemical Sciences·Debaditya Mukhopadhyay, Mary Dasso
Sep 5, 2007·Trends in Cell Biology·Ronald Thomas Hay
Oct 12, 2007·Nature Reviews. Molecular Cell Biology·Rosa Bernardi, Pier Paolo Pandolfi
Nov 7, 2007·Nature Structural & Molecular Biology·Sean D TavernaDinshaw J Patel
Nov 27, 2007·Nature Reviews. Molecular Cell Biology·Alexander J RuthenburgC David Allis
Oct 24, 2008·Molecular Biology of the Cell·Ulf R KleinStefan Muller
Feb 17, 2009·Molecular Cell·Per Stehmeier, Stefan Muller
May 29, 2009·Nature Reviews. Molecular Cell Biology·Marie-Claude Geoffroy, Ronald T Hay
Jun 16, 2009·Cellular and Molecular Life Sciences : CMLS·Miia M RytinkiJorma J Palvimo
Oct 31, 2009·Chemistry & Biology·Kinga Kamieniarz, Robert Schneider
May 12, 2010·Journal of Cellular Physiology·Amrita CheemaMaria Laura Avantaggiati
May 14, 2010·The Biochemical Journal·Kevin A Wilkinson, Jeremy M Henley
May 25, 2010·Nature Structural & Molecular Biology·Yonathan Lissanu DeribeIvan Dikic
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Jaclyn R Gareau, Christopher D Lima

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Citations

Apr 16, 2013·Chromosoma·Jérôme O RouvièreBenoit Palancade
Aug 7, 2013·Chromosoma·Nithya RamanStefan Muller
Jun 12, 2013·Annual Review of Biochemistry·Annette Flotho, Frauke Melchior
Aug 28, 2013·Neuromolecular Medicine·Katrin Eckermann
Aug 31, 2013·Neuromolecular Medicine·Mathias DroescherAndrea Pichler
Apr 3, 2013·The Journal of Cell Biology·Tharan SrikumarBrian Raught
Feb 20, 2014·FEBS Letters·Cristina GamellSue Haupt
Dec 9, 2014·Nucleus·Umut SahinValérie Lallemand-Breitenbach
May 23, 2014·The Biochemical Journal·Camy C-H KungTai-Huang Huang
Jan 19, 2013·Developmental Cell·Caelin Cubeñas-Potts, Michael J Matunis
Jul 21, 2016·Nature Reviews. Molecular Cell Biology·Ivo A Hendriks, Alfred C O Vertegaal
Jul 28, 2016·Biophysical Journal·Maxmore ChaibvaJustin Legleiter
Sep 15, 2016·Cell Reports·Kathrin KunzStefan Müller
Feb 7, 2017·PLoS Genetics·Heather A NewmanMichael J Matunis
Sep 1, 2012·Biomolecules·Catherine A CremonaXiaolan Zhao
Apr 30, 2013·Nature Reviews. Microbiology·Roger D EverettBenjamin G Hale
Oct 8, 2014·Physiological Reviews·Jeremy M HenleyKevin A Wilkinson
Jan 1, 2016·The Journal of Biological Chemistry· Anamika, Leo Spyracopoulos
Sep 8, 2017·Cellular and Molecular Life Sciences : CMLS·Vanesa LafargaMaria T Berciano
Dec 25, 2019·Biochemical Society Transactions·Nathalia VarejãoDavid Reverter
Feb 26, 2020·The FEBS Journal·Arnab Nayak, Mamta Amrute-Nayak
Mar 12, 2017·Biomolecular Concepts·Andrea PichlerNathalie Eisenhardt
Jul 16, 2020·Physiological Reviews·Hui-Ming Chang, Edward T H Yeh
Jan 20, 2017·Experimental and Therapeutic Medicine·Zhijian SangYoucheng Yu
Apr 26, 2018·Frontiers in Plant Science·Magdalena FüßlIris Finkemeier
Aug 3, 2019·Cells·Ariane Abrieu, Dimitris Liakopoulos
Oct 18, 2020·Nucleic Acids Research·Armelle CorpetPatrick Lomonte
Mar 11, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaoming LiuKe Cao
Jan 22, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wenhui LiuNian Fu
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mathias BoulangerGuillaume Bossis
Apr 30, 2020·Structure·Mathieu Lussier-PriceJames G Omichinski
Jun 13, 2020·Trends in Cancer·Yuwen LiGuoyu Meng
May 25, 2021·Frontiers in Molecular Biosciences·Jan Keiten-SchmitzStefan Müller

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