An acquired stable variant of a dicentric dic(9;20) and complex karyotype in a Syrian childhood B-acute lymphoblastic leukemia case

Molecular Cytogenetics
Abdulsamad WafaWalid Al-Achkar

Abstract

About 25 years ago, the acquired chromosome abnormality dicentric dic(9;20)(p11 ~ 13;q11) was seen described as a non-random aberration in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Yet, about 200 cases were reported. However, dicentric dic(9;20) is a subtle abnormality which easily may be mixed up with monosomy 20 and/or del(9p). The dicentric dic(9;20) can be found as a sole chromosomal abnormality or can be masked within complex rearrangements; also, a dicentric dic(9;20) is often associated with mono- or biallelic loss of CDKN2A gene. Here we report a case of 16-year-old male diagnosed with a de novo pre-B-ALL. Molecular approaches (array-based multicolor banding (aMCB) and array comparative genomic hybridization (aCGH)) were applied, and a unique complex karyotype involving six chromosomes was identified. It included three previously unreported chromosomal aberrations: dicentric dic(9;20;X), deletion del(7)(p22.2p15.2) and dicentric dic(7;13). The dicentric dic(9;20;X) also led to monoallelic loss of tumor suppressor gene CDKN2A. After successful chemotherapeutic treatment the patient experienced a relapse with a secondary ALL without complex karyotype but a deletion del(19)(p13). Unfortunately, the patient d...Continue Reading

References

Apr 1, 1992·Cancer Genetics and Cytogenetics·M SilengoE Madon
Sep 1, 1990·Genes, Chromosomes & Cancer·D R BettsB Gibbons
May 1, 1995·Genes, Chromosomes & Cancer·H RiederC Fonatsch
Dec 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Anna AnderssonThoas Fioretos
Jan 17, 2008·Blood·Fiona E Craig, Kenneth A Foon
Sep 5, 2008·Current Protocols in Cytometry·C C Stewart, S J Stewart
Feb 24, 2015·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Moneeb A K OthmanThomas Liehr

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