PMID: 1213686Dec 1, 1975Paper

An acrosin inhibitor in ram spermatozoa that does not originate from the seminal plasma

Hoppe-Seyler's Zeitschrift für physiologische Chemie
C R Brown, E F Hartree

Abstract

Ram seminal plasma, and ejaculated ram spermatozoa that have been washed with 0.25M sucrose, both contain acrosin inhibitor. The aim of this work was to determine whether the intracellular inhibitor originates from the seminal plasma. The amounts of inhibitor in ejaculated and epididymal spermatozoa were measured and compared with the amounts present in the seminal plasma of normal and vasectomized rams. One ejaculated ram spermatozoon contained 2.1 amol (2.1 X 10(-18) mol) of inhibitor and one epididymal spermatozoon contained 3.3 amol of inhibitor. (All molarities are mean values based on pooled ram semen or on single ejaculates from three vasectomized rams.) Calculations from results in earlier publications indicated that one ejaculated ram spermatozoon contains about 3 amol of acrosin; thus the inhibitor: acrosin ratio in washed ram spermatozoa is approximately 1. One ml of ram semen contains, on average, 3 X 10(9) spermatozoa and not more than 0.8 ml of seminal plasma. This number of ejaculated spermatozoa would contain 6.3 nmol of inhibitor, while the same number of epididymal spermatozoa would contain 9.9 nmol of inhibitor. These values exceed the quantities of inhibitor present in 0.8 ml of normal seminal plasma (approx...Continue Reading

Citations

Jan 1, 1985·Anatomy and Embryology·J Pereda, M Coppo
Jun 1, 1979·Journal of Pharmaceutical Sciences·I H HallL J Loeffler
Sep 11, 1978·Biochimica Et Biophysica Acta·C R Brown, R A Harrison

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