An activating and cytotoxic effect of asbestos on polymorphonuclear leukocytes

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J G ElferinkH K Koerten

Abstract

Chrysotile asbestos induces extensive enzyme release from polymorphonuclear leukocytes (PMNs). The release of the cytoplasmic enzyme lactate dehydrogenase implies membrane damage and cytotoxicity. In the presence of extracellular Ca2+ asbestos exerts an activating effect, evident from the release of granule-associated enzymes by exocytosis. Both the cytotoxic and activating effect of asbestos may contribute to asbestos-induced tissue damage.

References

Aug 1, 1987·Annals of the Rheumatic Diseases·J G Elferink, M Deierkauf
Jan 1, 1982·International Archives of Allergy and Applied Immunology·N J DollJ E Salvaggio
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·B MossmanE Wei

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Citations

Jan 1, 1990·Molecular Aspects of Medicine·A Shock, G J Laurent
Dec 15, 2007·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Bojana B PetanjekDubravka Vrankovic
Nov 1, 1991·Toxicology and Applied Pharmacology·J ChenJ A Last
Jan 12, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Nahed El-NajjarAndré Gessner

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