An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse

Experimental Eye Research
Jonathan G CrowstonVicki Chrysostomou

Abstract

We describe a model of acute intraocular pressure (IOP) elevation in the mouse eye that induces reversible loss of inner retinal function associated with oxidative stress, glial cell activation and minimal loss of retinal ganglion cell (RGC) number. Young healthy mouse eyes recover inner retinal function within 7-days but more persistent functional loss is seen in older mice. Manipulation of diet and exercise further modify RGC recovery demonstrating the utility of this injury model for investigating lifestyle and therapeutic interventions. We believe that systematic investigation into the characteristics and determinants of RGC recovery following an IOP challenge will shed light on processes that govern RGC vulnerability in the early stages of glaucoma.

References

Dec 30, 2004·Investigative Ophthalmology & Visual Science·Stefano A GandolfiMaria Grazia Tardini
Mar 11, 2008·Investigative Ophthalmology & Visual Science·Vicki ChrysostomouKrisztina Valter
Aug 1, 2009·Investigative Ophthalmology & Visual Science·Yu X KongV Bang Bui
Jan 6, 2012·Neurobiology of Aging·Yu Xiang George KongJonathan G Crowston
Jan 17, 2013·Investigative Ophthalmology & Visual Science·Ming Lye-BarthelTatjana C Jakobs
Apr 11, 2013·Investigative Ophthalmology & Visual Science·Jelena M KezicJonathan G Crowston
May 8, 2013·Glia·Daniel SunTatjana C Jakobs
Jun 15, 2013·Investigative Ophthalmology & Visual Science·Vicki Chrysostomou, Jonathan G Crowston
Feb 15, 2014·Neurobiology of Aging·Vicki ChrysostomouJonathan G Crowston

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Citations

Jun 28, 2015·Experimental Eye Research·Kimberly A FernandesRichard T Libby
Jun 12, 2016·Pharmacology & Therapeutics·M I G Lopez SanchezI A Trounce
Jan 7, 2017·Eye·J G CrowstonV Chrysostomou
Feb 1, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·V ChrysostomouJ G Crowston
Mar 15, 2018·Scientific Reports·Shandiz TehraniJohn C Morrison
Sep 3, 2019·Current Eye Research·Tasneem Z Khatib, Keith R Martin
Apr 19, 2017·The Journal of Experimental Medicine·Daniel SunTatjana C Jakobs
Aug 4, 2020·Translational Vision Science & Technology·Tilvawala GopeshRobert N Weinreb
Oct 11, 2017·Molecular Medicine Reports·Jinhui WangYufu Liu
Jan 12, 2020·Scientific Reports·Kayla R FicarrottaChristopher L Passaglia
Aug 30, 2017·Frontiers in Cellular Neuroscience·Farraj AlbalawiClaire H Mitchell
Jan 30, 2021·Translational Vision Science & Technology·James R TribblePete A Williams
Jul 3, 2021·Cells·Vittorio Porciatti, Tsung-Han Chou

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