Jun 24, 2014

An acyl-SAM analog as an affinity ligand for identifying quorum sensing signal synthases

Chemical Communications : Chem Comm
Kenji KaiHideo Hayashi


N-Acylhomoserine lactones (AHLs) are quorum sensing signals produced by Gram-negative bacteria. We here report the affinity purification of AHL synthases using beads conjugated with an enzyme inhibitor, which was designed based on the catalytic intermediate acyl-SAM.

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Mentioned in this Paper

Enzyme Inhibitor Drugs
Structure-Activity Relationship
Anterior Horizontal Limb of Lateral Sulcus (Human Only)
Gram-Negative Bacteria
Molecular Docking Analysis
Ligands Activity
Enzyme Inhibitors
Butyrylhomoserine Lactones

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