An Adaptive Chlamydia trachomatis -Specific IFN-γ-Producing CD4+ T Cell Response Is Associated With Protection Against Chlamydia Reinfection in Women

Frontiers in Immunology
Rakesh K BakshiWilliam M Geisler

Abstract

Background: Adaptive immune responses that mediate protection against Chlamydia trachomatis (CT) remain poorly defined in humans. Animal chlamydia models have demonstrated that CD4+ Th1 cytokine responses mediate protective immunity against reinfection. To better understand protective immunity to CT in humans, we investigated whether select CT-specific CD4+ Th1 and CD8+ T cell cytokine responses were associated with protection against CT reinfection in women. Methods: Peripheral blood mononuclear cells were collected from 135 CT-infected women at treatment and follow-up visits and stimulated with CT antigens. CD4+ and CD8+ T-cells expressing IFN-γ, TNF-α, and/or IL-2 were assessed using intracellular cytokine staining and cytokine responses were compared between visits and between women with vs. without CT reinfection at follow-up. Results: A CD4+TNF-α response was detected in the majority (77%) of study participants at the treatment visit, but a lower proportion had this response at follow-up (62%). CD4+ IFN-γ and CD4+ IL-2 responses occurred less frequently at the treatment visit (32 and 18%, respectively), but increased at follow-up (51 and 41%, respectively). CD8+ IFN-γ and CD8+ TNF-α responses were detected more often at f...Continue Reading

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Citations

Mar 2, 2019·The Journal of Infectious Diseases·Taylor B PostonXiaojing Zheng
Aug 31, 2019·Journal of the International AIDS Society·Ruth MwatelahSalim S Abdool Karim
Apr 17, 2019·Journal of Bacteriology·Timothy L Yahr, Craig D Ellermeier
Jul 7, 2020·Frontiers in Cellular and Infection Microbiology·Hong WangXi Yang
Mar 9, 2021·Expert Review of Vaccines·Luis M de la MazaSukumar Pal
Feb 21, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenhao NiuHong Bai
Mar 28, 2021·Vaccine·Sam M Murray, Paul F McKay
Jun 8, 2021·Frontiers in Immunology·Wenjing XiangZhou Zhou

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

FlowJo
R
TreeStar
SAS

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