An Adult Case of Generalized Convulsions Caused by the Ingestion of Ginkgo biloba Seeds with Alcohol

Internal Medicine
Fumika AzumaKeiji Wada

Abstract

A 64-year-old woman developed symptoms of vomiting and tonic-clonic convulsions 9.5 h after eating 50 roasted Ginkgo biloba seeds with 100 g of alcohol. The intravenous administration of pyridoxal phosphate effectively improved the symptoms. Blood samples were collected and stored over 35 h. The assessment of 4'-O-methylpyridoxine and vitamin B6 vitamers indicated high levels of both, but the pyridoxal phosphate levels were low during the acute stage. These results suggest that 4'-O-methylpyridoxine inhibits the transformation of vitamin B6 analogues to the active form, pyridoxal phosphate. In our case, alcohol may have extended the period until ginkgo intoxication appeared.

References

Aug 1, 1985·Chemical & Pharmaceutical Bulletin·K WadaM Haga
Mar 8, 2000·International Journal for Parasitology·I MollaretJ L Justine
Feb 5, 2002·Pediatrics·Yo KajiyamaYutaka Manabe
Aug 13, 2002·Chemical Communications : Chem Comm·Varinder K AggarwalAndrea Mereu
Feb 26, 2003·Clinical Chemistry·Dinesh TalwarDenis St J O'Reilly
Jun 10, 2006·Journal of Inherited Metabolic Disease·Peter T Clayton
Sep 26, 2006·Pediatric Neurology·Shunji HasegawaSusumu Furukawa
Nov 20, 2008·JAMA : the Journal of the American Medical Association·Steven T DeKoskyUNKNOWN Ginkgo Evaluation of Memory (GEM) Study Investigators
May 9, 2014·The American Journal of Clinical Nutrition·Monique AlbersenNanda M Verhoeven-Duif
Jan 29, 2016·Journal of Epilepsy Research·Hyun-Soon JangMun Kyung Sunwoo
Jan 4, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tomoyuki AkiyamaKatsuhiro Kobayashi
Jan 6, 2017·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Nan MeiLei Guo
Dec 22, 2017·Neuron·Karina P AbrahaoDavid M Lovinger
Oct 5, 2018·Journal of Pharmaceutical and Biomedical Analysis·Yiyun QianJin-Ao Duan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Related Papers

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Daisuke Kobayashi
Journal of the Society for Integrative Oncology
© 2021 Meta ULC. All rights reserved