An Advanced AIDS Patient With CD4 <20 and Plasmablastic Lymphoma Achieving Complete Response With the V-EPOCH Regimen

Curēus
Blessie NelsonRohit Venkatesan

Abstract

Plasmablastic lymphoma (PBL) is a rare form of non-Hodgkin lymphoma that is highly aggressive and carries a poor prognosis. Although the standard chemotherapy choice for most diffuse large B-cell lymphomas (DLBCL) is R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone), subtypes of DLBCL such as PBL are less responsive to this treatment regimen. The preferred regimens for PBL include infusional EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin hydrochloride), HyperCVAD (cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride, and dexamethasone), or CODOX-M/IVAC (cyclophosphamide, vincristine, doxorubicin, high-dose methotrexate/ifosfamide, etoposide, and high-dose cytarabine). Recent studies have begun to investigate the addition of other agents to these regimens to improve survival. This case report is about a patient with a history of advanced acquired immunodeficiency syndrome (AIDS) with a cluster of differentiation 4 (CD4) count <20 who had CD20 negative plasmablastic lymphoma and was successfully treated with the combination of bortezomib and dose-adjusted EPOCH (V-EPOCH) and intrathecal chemotherapy, achieving complete response with optimal tolerance. To our k...Continue Reading

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Aug 30, 2008·American Journal of Hematology·Jorge CastilloBruce J Dezube
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kristopher A SarosiekIzidore S Lossos
Jul 16, 2011·American Journal of Clinical Pathology·Eric D HsiAhmet Dogan
Sep 11, 2014·World Journal of Gastroenterology : WJG·Lynette LuriaLing Zhang
Jan 24, 2015·British Journal of Haematology·Jorge J CastilloEric S Winer
Jan 24, 2016·Annals of Hematology·Pasquale L FedeleGeorge Grigoriadis
Mar 13, 2018·British Journal of Haematology·Jorge J CastilloMichele Bibas
Jun 15, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Andrew D ZelenetzHema Sundar

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BETA
biopsy

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