An advanced magnetic resonance imaging perspective on the etiology of deep tissue injury

Journal of Applied Physiology
Jules L NelissenGustav J Strijkers

Abstract

Early diagnosis of deep tissue injury remains problematic due to the complicated and multifactorial nature of damage induction and the many processes involved in damage development and recovery. In this paper, we present a comprehensive assessment of deep tissue injury development and remodeling in a rat model by multiparametric magnetic resonance imaging (MRI) and histopathology. The tibialis anterior muscle of rats was subjected to mechanical deformation for 2 h. Multiparametric in vivo MRI, consisting of T2, T2*, mean diffusivity (MD), and angiography measurements, was applied before, during, and directly after indentation as well as at several time points during a 14-day follow-up. MRI readouts were linked to histological analyses of the damaged tissue. The results showed dynamic change in various MRI parameters, reflecting the histopathological status of the tissue during damage induction and repair. Increased T2 corresponded with edema, muscle cell damage, and inflammation. T2* was related to tissue perfusion, hemorrhage, and inflammation. MD increase and decrease was reported on the tissue's microstructural integrity and reflected muscle degeneration and edema as well as fibrosis. Angiography provided information on bloc...Continue Reading

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Citations

Nov 7, 2018·Computer Methods in Biomechanics and Biomedical Engineering·Willeke A TraaCees W J Oomens
Mar 22, 2019·NMR in Biomedicine·Jules L NelissenGustav J Strijkers
Nov 5, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Nele Van DammeDimitri Beeckman
Jun 21, 2019·Advances in Skin & Wound Care·Amit GefenNick Santamaria
Mar 19, 2021·British Journal of Nursing : BJN·Matthew Wynn
Aug 13, 2021·International Wound Journal·Amit GefenJan Kottner

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Software Mentioned

Mathematica
R
Matlab
R environment
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