An Advanced View on Baculovirus per Os Infectivity Factors

Insects
Bob BoogaardJan W M van Lent

Abstract

Baculoviruses are arthropod-specific large DNA viruses that orally infect the larvae of lepidopteran, hymenopteran and dipteran insect species. These larvae become infected when they eat a food source that is contaminated with viral occlusion bodies (OBs). These OBs contain occlusion-derived viruses (ODVs), which are released upon ingestion of the OBs and infect the endothelial midgut cells. At least nine different ODV envelope proteins are essential for this oral infectivity and these are denoted per os infectivity factors (PIFs). Seven of these PIFs form a complex, consisting of PIF1, 2, 3 and 4 that form a stable core complex and PIF0 (P74), PIF6 and PIF8 (P95) that associate with this complex with lower affinity than the core components. The existence of a PIF complex and the fact that the pif genes are conserved in baculovirus genomes suggests that PIF-proteins cooperatively mediate oral infectivity rather than as individual functional entities. This review therefore discusses the knowledge obtained for individual PIFs in light of their relationship with other members of the PIF complex.

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Citations

Jan 30, 2019·The Journal of General Virology·Bob BoogaardMonique M van Oers
Feb 13, 2019·PloS One·Tomás MassonVíctor Romanowski
Jan 4, 2019·Journal of Virology·Xi WangZhihong Hu
May 3, 2020·Neotropical Entomology·D R Sosa-GómezB M Ribeiro
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Manli Wang, Zhihong Hu
Jul 5, 2019·Insects·Monique M van Oers, Jørgen Eilenberg
Nov 15, 2020·Applied and Environmental Microbiology·Inés BeperetPrimitivo Caballero
Feb 17, 2021·The Journal of General Virology·Michael J ArvinMichael R Strand
Feb 27, 2021·Frontiers in Immunology·Liang JiangQingyou Xia
May 23, 2019·Current Opinion in Insect Science·Gaelen R Burke

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Methods Mentioned

BETA
co-immunoprecipitation
immunoprecipitation
nuclear translocation

Software Mentioned

Phobuis
Phobius
software

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