An aerobiological model of aerosol survival of different strains of Pseudomonas aeruginosa isolated from people with cystic fibrosis

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
I J CliftonDaniel Peckham

Abstract

Pseudomonas aeruginosa is a common and important pathogen in people with cystic fibrosis (CF). Recently epidemic strains of P. aeruginosa associated with increased morbidity, have been identified. The method of transmission is not clear, but there is evidence of a potential airborne route. The aim of this study was to determine whether different strains of P. aeruginosa isolated from people with CF were able to survive within artificially generated aerosols in an aerobiological chamber. Viable P. aeruginosa could still be detected up to 45min after halting generation of the aerosols. All of the strains of P. aeruginosa expressing a non-mucoid phenotype isolated from people with CF had a reduced ability to survive within aerosols compared to an environmental strain. Expression of a mucoid phenotype by the strains of P. aeruginosa isolated from people with CF promoted survival in the aerosol model compared to strains expressing a non-mucoid phenotype.

References

Aug 1, 1991·The American Review of Respiratory Disease·E A NardellS C Etkind
Nov 1, 1989·American Industrial Hygiene Association Journal·J M Macher
Apr 5, 2002·Clinical Microbiology Reviews·Jeffrey B LyczakGerald B Pier
May 8, 2003·Journal of Clinical Microbiology·David ArmstrongClaire Wainwright
Jun 14, 2008·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Agnès FerroniIsabelle Sermet-Gaudelus

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Citations

May 6, 2015·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Pieter C GoeminneLieven J Dupont
Jul 16, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Lisa SaimanDavid J Weber
Sep 3, 2013·Journal of Proteome Research·Nichollas E ScottStuart J Cordwell
Sep 15, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Scott C BellRhonda L Stuart
Sep 24, 2016·The European Respiratory Journal·Louise A FletcherIan J Clifton
Jul 28, 2010·Expert Review of Respiratory Medicine·Ian J Clifton, Daniel G Peckham
Aug 28, 2018·Current Pulmonology Reports·Philip MitchelmoreDavid Hettle
Aug 31, 2018·Clinical Microbiology Reviews·Michael D ParkinsValerie J Waters
Oct 25, 2017·Pediatrics·Mobeen H RathoreUNKNOWN COMMITTEE ON INFECTIOUS DISEASES

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