Dec 1, 1993

An age-specific kinetic model of lead metabolism in humans

Environmental Health Perspectives
R W Leggett

Abstract

Although considerable progress has been made in recent years in reducing human exposures to lead, the potential for high intake of this contaminant still exists in millions of homes and in many occupational settings. Moreover, there is growing evidence that levels of lead intake considered inconsequential just a few years ago can result in subtle, adverse health effects, particularly in children. Consequently, there have been increased efforts by health protection agencies to develop credible, versatile methods for relating levels of lead in environmental media to levels in blood and tissues of exposed humans of all ages. In a parallel effort motivated largely by the Chernobyl nuclear accident, the International Commission on Radiological Protection (ICRP) is assembling a set of age-specific biokinetic models for calculating radiation doses from environmentally important radionuclides, including radioisotopes of lead. This paper describes a new age-specific biokinetic model for lead originally developed for the ICRP but expanded to include additional features that are useful for consideration of lead as a chemical toxin. The model is developed within a generic, physiologically motivated framework designed to address a class of ...Continue Reading

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  • Citations117

References

Mentioned in this Paper

Metabolic Process, Cellular
Toxin
Red blood cells, blood product
Brain
Senility
Kidney
Toxicology
Metabolic Pathway
Diffusion
Red Blood Cell Count Measurement

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