An Age-Standardized Prevalence Estimate and a Sex and Age Distribution of Myotonic Dystrophy Types 1 and 2 in the Rome Province, Italy

Neuroepidemiology
Nicola VanacoreRoberto Massa

Abstract

Prevalence estimates for the 2 forms of myotonic dystrophy types 1 and 2 (DM1 and DM2) are not exhaustive or non-available. Our aim was to estimate the minimum prevalence of DM1 and DM2 in Italy in the Rome province, applying standards of descriptive epidemiology. All patients with a molecular diagnosis of DM1/DM2 and residents in the Rome province in 2013 have been enrolled, and the age-standardized prevalence has been calculated, assuming a Poisson distribution and adjusting for age. We identified 395 DM1 patients: the age-standardized prevalence for total, females and males was 9.65, 8.35 and 11.07/100,000, respectively. The mean age of subjects differed considerably according to CTG repeat length (p = 0.001). Forty DM2 patients were identified. The age-standardized prevalence for total, females and males was 0.99, 1.07 and 0.90/100,000, respectively. The mean age was 57.05. We estimated for the first time the age-standardized prevalence and the sex and age distribution of DM1 and DM2 in a general population. A higher prevalence of males in DM1 and females in DM2 and a higher mean age of DM2 patients (+8 years) were ascertained. Prevalence of DM2 was 10% that of DM1. These prevalence values are probably lower than mutational...Continue Reading

Citations

Nov 1, 2017·Journal of Neurology·Federica MontagneseBenedikt Schoser
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Jan 16, 2020·International Journal of Molecular Sciences·Stéphanie Tomé, Geneviève Gourdon
Jul 6, 2018·Frontiers in Neurology·Alexis S MahyeraWolfram Kress
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Mar 7, 2021·International Journal of Environmental Research and Public Health·Tiago MateusSandra Rebelo
May 1, 2021·International Journal of Environmental Research and Public Health·Tiago MateusSandra Rebelo
Jun 26, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Valeria A SansoneRoberto Massa
Jul 11, 2021·Neuromuscular Disorders : NMD·Stojan PericGiovanni Meola
Nov 28, 2021·International Journal of Molecular Sciences·Virginia Veronica ViscontiAnnalisa Botta

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