An agonist of human complement fragment C5a enhances vaccine immunity against Coccidioides infection.

Vaccine
Chiung-Yu HungGarry T Cole

Abstract

Coccidioides is a fungal pathogen and causative agent of a human respiratory disease against which no clinical vaccine exists. In this study we evaluated a novel vaccine adjuvant referred to as EP67, which is a peptide agonist of the biologically active C-terminal region of human complement component C5a. The EP67 peptide was conjugated to live spores of an attenuated vaccine strain (ΔT) of Coccidioides posadasii. The non-conjugated ΔT vaccine provided partial protection to BALB/c mice against coccidioidomycosis. In this report we compared the protective efficacy of the ΔT-EP67 conjugate to the ΔT vaccine in BALB/c mice. Animals immunized subcutaneously with the ΔT-EP67 vaccine showed significant increase in survival and decrease in fungal burden over 75 days postchallenge. Increased pulmonary infiltration of dendritic cells and macrophages was observed on day 7 postchallenge but marked decrease in neutrophil numbers had occurred by 11 days. The reduced influx of neutrophils may have contributed to the observed reduction of inflammatory pathology. Mice immunized with the ΔT-EP67 vaccine also revealed enhanced expression of MHC II molecules on the surface of antigen presenting cells, and in vitro recall assays of immune splenocy...Continue Reading

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Citations

Dec 25, 2013·PLoS Pathogens·Garry T ColeStuart M Levitz
Nov 8, 2013·Current Infectious Disease Reports·Trent R Malcolm, Peter V Chin-Hong
Nov 18, 2015·Immunological Investigations·Kausik Datta, Mawieh Hamad
Jun 27, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bala Vamsi K KaruturiJoseph A Vetro
Mar 17, 2017·Microorganisms·Natalia Castro-Lopez, Chiung-Yu Hung
Sep 19, 2017·Nature Reviews. Immunology·Edimara S ReisJohn D Lambris
Apr 16, 2013·Current Fungal Infection Reports·Garry T ColeChiung-Yu Hung
Nov 17, 2016·Drug Delivery and Translational Research·Amit Kumar Chaudhary, Ram I Mahato
Jan 29, 2019·Medical Mycology·Chiung-Yu HungJoshua Fierer
Jul 12, 2017·Mediators of Inflammation·Juliana Alves Parente-RochaMaristela Pereira
Oct 2, 2019·Frontiers in Immunology·Marley C Caballero Van DykeBridget M Barker
Jan 12, 2021·Frontiers in Cellular and Infection Microbiology·Juan David Puerta-AriasÁngel González
Dec 3, 2020·Frontiers in Cellular and Infection Microbiology·Anh L Diep, Katrina K Hoyer
Apr 4, 2021·Cancers·Rebecca M O'BrienNiamh Lynam-Lennon
Jun 3, 2021·Journal of Fungi·Rebecca A WardJatin M Vyas

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