An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia.

Journal of Lipid Research
Kelly R AtkinsonSCOPE Consortium

Abstract

Preeclampsia is a common pregnancy complication that is an important cause of preterm birth and fetal growth restriction. Because there is no diagnostic test yet available for preeclampsia, we used a proteomic approach to identify novel serum/plasma biomarkers for this condition. We conducted case control studies comparing nulliparous women who developed preeclampsia at 36-38 weeks of gestation with healthy nulliparous women matched by gestational age at sampling. Serum/plasma was depleted of six abundant proteins and analyzed by two-dimensional gel electrophoresis (n = 12 per group) and difference gel electrophoresis (n = 12 per group). Differences in abundance of protein spots were detected by univariate and multivariate statistical analyses. Proteins were identified by mass spectrometry and expression of selected proteins was validated by immunoblotting. Proteins whose concentrations were selectively associated with preeclampsia included apolipoprotein E (apoE), apoC-II, complement factor C3c, fibrinogen, transthyretin, and complement factor H-related protein 2. An increase in a deglycosylated isoform of apoE3 and concomitantly decreased amounts of one apoE3 glycoisoform were identified in preeclamptic plasma and confirmed b...Continue Reading

References

Nov 15, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·H M WilsonE R Skinner
Sep 1, 1995·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J GardosiA Chang
Feb 1, 1996·British Journal of Obstetrics and Gynaecology·H J van den ElzenD E Grobbee
Jul 11, 1998·Journal of Clinical Pathology·B NagyT Tóth
Dec 10, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·J FrancoualA Lindenbaum
Aug 5, 2000·The Australian & New Zealand Journal of Obstetrics & Gynaecology·M A BrownUNKNOWN Austalasian Society of the Study of Hypertension in Pregnancy
Dec 19, 2000·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·A B ChikosiL Rom
Jul 31, 2001·Journal of Clinical Pathology·N MakkonenP Kirkinen
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Christophe Ambroise, Geoffrey J McLachlan
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert TibshiraniGilbert Chu
Aug 15, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jeanne FrancoualRené Frydman
Jan 9, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jacqueline ChalasAlbert Lindenbaum
Dec 23, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Luís BeloIrene Rebelo
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
May 10, 2005·Proteomics·Natascia CampostriniPier Giorgio Righetti
Jun 1, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Renu ShankarEric K Moses
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
May 4, 2006·The Journal of Clinical Investigation·Robert W MahleyKarl H Weisgraber
Jul 4, 2006·American Journal of Obstetrics and Gynecology·Roberta B Ness, Baha M Sibai
Jul 6, 2006·Trends in Biochemical Sciences·Danny M HattersKarl H Weisgraber
Jul 14, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·J C HeitnerM O Glocker
Sep 9, 2006·Current Opinion in Lipidology·Geoffrey J Howlett, Kathryn J Moore
Jan 6, 2007·Journal of Proteome Research·Carlo VascottoFranco Quadrifoglio
Mar 3, 2007·The Journal of Clinical Investigation·Tomas VaisarJay W Heinecke
Jun 23, 2007·Current Pharmaceutical Design·A I KakafikaD P Mikhailidis
Nov 3, 2007·BMJ : British Medical Journal·Leanne BellamyDavid J Williams
Dec 11, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Vaughan K WilliamsWilliam M Hague
Jan 29, 2008·Journal of Proteome Research·Simone SchröderHermann Wätzig
Jan 29, 2008·Placenta·J M RobinsonD D Vandré
Feb 2, 2008·Journal of Proteome Research·Kristina Nedenskov JensenBo M Jørgensen
Nov 1, 2008·Placenta·E Basatemur, A Sutcliffe

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Citations

Oct 13, 2012·Molecular & Cellular Proteomics : MCP·Shannon K Flood-NicholsDanielle L Ippolito
Sep 19, 2009·PLoS Computational Biology·Steven H WuAllen G Rodrigo
Aug 28, 2009·Journal of Perinatal Medicine·Edi VaisbuchJuan Pedro Kusanovic
Dec 12, 2012·Pharmacogenomics and Personalized Medicine·Paula Juliet Williams, Linda Morgan
Aug 15, 2014·PloS One·Olga V SavinovaGregory C Shearer
Aug 4, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Wei YuanAndrés López Bernal
May 10, 2012·Journal of Biomedicine & Biotechnology·Varaprasad KollaSinuhe Hahn
Jan 10, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·L M ProcopciucF Stamatian
Mar 14, 2014·Redox Biology·Helen R GriffithsAndrew Devitt
Apr 12, 2017·Journal of Lipid Research·Hiten D MistryGeneviève Escher
Jun 13, 2013·Reproductive Sciences·Shannon K Flood-NicholsDanielle L Ippolito
Jun 22, 2010·American Journal of Reproductive Immunology : AJRI·Meenal AgarwalSuraksha Agrawal
Sep 1, 2011·Mass Spectrometry Reviews·Peihong ZhuJohn G Marshall
Mar 27, 2012·Proteomics. Clinical Applications·Sheon MaryAshok P Giri
Apr 24, 2014·Expert Review of Proteomics·Mary F LopezMingMing Ning
Jun 6, 2013·Experimental and Therapeutic Medicine·Engin KorkmazerOguz Cilingir
Feb 23, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Arrigo FruscalzoDiego Marchesoni

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