An altered peptide ligand of type II collagen suppresses autoimmune arthritis

Critical Reviews in Immunology
Linda K MyersAndrew H Kang

Abstract

On the basis of the hypothesis that immunity to type II collagen (CII) contributes to joint inflammation, our goal is to develop an immunotherapy capable of selectively blocking immunity to a particular autoantigen without interfering with the beneficial functions of the immune system. CII is the major protein component of articular cartilage and autoimmunity to CII is strongly associated with rheumatoid arthritis in man. Our laboratory has previously identified a region of type II collagen (CII), CII245-270 that contains a prominent T-cell epitope in the immune response to CII. Residues critical to the I-Aq-restricted presentation of this determinant have been characterized. When synthetic analog peptides were developed that contain site-directed substitutions in critical positions, we found that that CII245-270 (A260, B261, N263) (A9), profoundly suppressed collagen-induced arthritis. When DBA/1 mice were coimmunized with CII and the analog peptide, the incidence and severity of arthritis was greatly reduced concordant with the humoral immune responses to CII. Moreover, the suppression could be transferred with A9-immune spleen cells and was accompanied by a Th2-type cytokine profile. When we compared T-cell signals in respon...Continue Reading

Citations

Apr 19, 2012·The Journal of Biological Chemistry·Jeoung-Eun ParkLinda K Myers
Nov 8, 2008·Expert Opinion on Biological Therapy·Maria KatsaraVasso Apostolopoulos
Nov 12, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeoung-Eun ParkLinda K Myers
Apr 21, 2018·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jeoung-Eun ParkLinda K Myers
Feb 23, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Audrey PageFrançois-Loïc Cosset

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