An altered peripheral IL6 response in major depressive disorder

Neurobiology of Disease
Kelli M MoneyKaroly Mirnics

Abstract

Major depressive disorder (MDD) is one of the most prevalent major psychiatric disorders with a lifetime prevalence of 17%. Recent evidence suggests MDD is not only a brain dysfunction, but a systemic disease affecting the whole body. Central and peripheral inflammatory changes seem to be a centerpiece of MDD pathology: a subset of patients show elevated blood cytokine and chemokine levels that partially normalize with symptom improvement over the course of anti-depressant treatment. As this inflammatory process in MDD is poorly understood, we hypothesized that the peripheral tissues of MDD patients will respond differently to inflammatory stimuli, resulting in an aberrant transcriptional response to elevated pro-inflammatory cytokines. To test this, we used MDD patient- and control-derived dermal fibroblast cultures to investigate their response to an acute treatment with IL6, IL1β, TNFα, or vehicle. Following RNA isolation and subsequent cDNA synthesis, quantitative PCR was used to determine the relative expression level of several families of inflammation-responsive genes. Our results showed comparable expression of the tested genes between MDD patients and controls at baseline. In contrast, MDD patient fibroblasts had a dim...Continue Reading

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Feb 10, 2017·Eye & Contact Lens·Anat GalorDouglas M Wallace
Feb 17, 2017·Pharmacological Reviews·Michael J Berridge
Mar 24, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zixuan CaiChao Huang

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