PMID: 13575682Oct 1, 1958Paper

An alternative mechanism for the properdin system

The Journal of Experimental Medicine
R A NELSON

Abstract

Evidence is presented that phenomena ascribed to the properdin system may be explained in terms of classical antibody (Ab) in combination with three of the components of complement (C'), i.e., C'(1), C'(4), and C'(2) respectively. The results suggest that the complex of properdin (P) with zymosan (Z) represents a mixture of Z.Ab, Z.Ab.C'(1, 4), Z.Ab-C'(1, 4, 2), and Z.Ab.C'(1, 4, 2) in a decayed state. The purported preferential reactivity of Z with the third component of C' (C'(3)) is not supported by the present experiments in which Z was reacted with C' in both guinea pig and human sera. Approximately the same number of reactive units of C'(1, 4) and of C'(3) were inactivated by Z, as well as by D. pneumoniae and a washed specific precipitate of bovine albumin-anti-albumin. The latter evidence that small amounts of antigen-antibody complex fix significant amounts of C'(3) stands in contrast with the classical concept that C'(3) is not fixed in ordinary complement fixation reaction. The observed reactivity of C'(3) is explained on the basis of the present use of essentially undiluted serum as a source of C'(3) and of 37 degrees as the temperature for fixation. Ancillary data indicate that purified properdin contains Ab. In th...Continue Reading

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