PMID: 6111739Feb 1, 1981Paper

An alternative mechanism of actions for neuroleptic and antidepressant drugs

Medical Hypotheses
P L Randall

Abstract

It has earlier been proposed by the author that the aetiology of schizophrenic symptomatology may be due to the presence of abnormally connected interhemispheric fibres which link specialised functions in the brains of schizophrenics that are not connected in normal subjects, and that the neuroleptic drugs may produce their action through a local anaesthetic-like effect in suppression of conduction in these fibres. This line of thought has been extended here to consider the possible mechanism of action of the neuroleptic drugs in more detail, as well as that of the tricyclic antidepressant drugs which are derivatives of the phenothiazine group. Pharmacological similarities with the local anaesthetics both structurally and functionally have been considered, as well as the effects that these drug groups may have in common with the lithium salts. It has been suggested that these drugs all produce their primary effect on cell membranes, though not necessarily at the synapse, that the time course of their clinical effect may correlate with their incorporation into various cell membranes within the CNS, and that they may thus bring about a fundamental alteration in cell membrane microstructure. The possible role of electroconvulsive ...Continue Reading

References

Sep 15, 1978·European Journal of Pharmacology·Z YavinD Samuel
May 1, 1974·The British Journal of Psychiatry : the Journal of Mental Science·P J BeumontD H Wiles
May 1, 1974·The British Journal of Psychiatry : the Journal of Mental Science·P J BeumontD H Wiles
Sep 1, 1972·The British Journal of Psychiatry : the Journal of Mental Science·R Rosenthal, L B Bigelow
Jun 1, 1980·Medical Hypotheses·P L Randall
Jan 15, 1940·The Journal of Physiology·F J Philpot

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Citations

Mar 1, 1983·Medical Hypotheses·P L Randall
Mar 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·R Goodman

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