An alternative method for smear preparation of fine-needle aspiration cytology of cystic thyroid lesions: Evaluation of sample adequacy.

Diagnostic Cytopathology
José Cândido Caldeira Xavier-JúniorNeivio José Mattar

Abstract

Cystic thyroid lesions represent one of the most common causes of unsatisfactory fine-needle aspiration sampling. Thus, it is important to access the maximum number of follicular cells from cystic fluid in order to reduce unsatisfactory rates. We compared the traditional method of smearing with an alternative one. For each thyroid nodule, two smears were collected. Each smear was prepared using a distinct approach: either using the traditional technique or the alternative. Clinical data were taken from cytopathological request forms. The cytological aspects of the smears (eg, adequacy and number of cells) were observed during microscopy analysis. No cases were found to be suspicious for malignancy during ultrasound analysis (categories TR1 or TR2 according to ACR TI-RADS). Thirty-five cases were analyzed. For smears prepared using both the traditional and the alternative techniques, 20 and 4 cases, respectively, were unsatisfactory. In the 20 unsatisfactory traditional smear cases, 9 (45%) showed enough cells for diagnosis in cytospin and/or cell block samples; the four unsatisfactory alternative method cases showed the same. There was a statistical difference between the two methods of collecting a smear concerning sample adeq...Continue Reading

References

Feb 15, 2002·Acta Cytologica·Meherbano M KamalHemant R Kulkarni
Feb 21, 2006·Thyroid : Official Journal of the American Thyroid Association·Rachel RedmanNicole A Massoll
Jan 29, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·F MayallK McAnulty
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Jun 20, 2017·Endocrine Journal·Nami TakadaAkira Miyauchi
Jul 22, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Güven Güney, İbrahim Tayfun Şahiner

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