PMID: 11376969May 30, 2001Paper

An alternative method to the evaluation of similarity factor in dissolution testing

International Journal of Pharmaceutics
P Costa

Abstract

This paper addresses an alternative method to the evaluation of similarity factor f(2) as a criterion for assessment of similarity between two in-vitro dissolution profiles as proposed in the SUPAC-IR Guidance (1995). Diltiazem hydrochloride Sustained-Release (SR) tablets were tested and the following independent-model dissolution parameters were used: t10% dissolution time, t25% dissolution time, t50% dissolution time, mean dissolution time (MDT), dissolution efficiency (DE) at t(120), and at t(360). To compare the dissolution profiles, several release models were tested such as Higuchi, zero order, first order, Baker-Lonsdale, Hixson-Crowell, Weibull and Korsmeyer-Peppas. The similarities between two in-vitro dissolution profiles were assessed by pair-wise independent-model procedures such as difference factor (f1), similarity factor (f2) and Rescigno index (xi1 and xi2). The in vitro release kinetics of diltiazem hydrochloride sustained release tablets were evaluated using USP apparatus 2.

References

Jun 1, 1978·The Journal of Pharmacy and Pharmacology·J A GoldsmithS D Ross
Jan 1, 1975·The Journal of Pharmacy and Pharmacology·K A Khan
Jul 1, 1992·Pharmaceutical Research·A Rescigno
Sep 30, 1992·Statistics in Medicine·L B Sheiner
Mar 1, 1992·Journal of Pharmaceutical Sciences·G K Vudathala, J A Rogers
Dec 1, 1972·The Journal of Pharmacy and Pharmacology·F Langenbucher
May 1, 1974·Journal of Pharmaceutical Sciences·J CobbyG C Walker
Oct 1, 1961·Journal of Pharmaceutical Sciences·T HIGUCHI

❮ Previous
Next ❯

Citations

Jan 24, 2009·Pharmaceutical Research·Vivian GrayStephen Mayock
Apr 25, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·F O CostaS J Formosinho
Nov 7, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Maria VertzoniChristos Reppas
May 16, 2009·AAPS PharmSciTech·Mukesh C Gohel, Shital H Bariya
Dec 17, 2010·AAPS PharmSciTech·Sanat Kumar BasuMani Rupeshkumar
Jul 1, 2009·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Yousef JavadzadehAli Nokhodchi
Jul 1, 2011·International Journal of Pharmaceutical Investigation·Hemant H GangurdeT Sivakumar
Oct 16, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Feifan XieZeneng Cheng
Jan 10, 2014·Drug Delivery·Yan ShenJiasheng Tu
Apr 1, 2015·Drug Development and Industrial Pharmacy·Amos Olusegun Abioye, Adeola Kola-Mustapha
Feb 6, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sasa BaumgartnerJulijana Kristl
Dec 11, 2007·International Journal of Pharmaceutics·Longxiao Liu, Xiangning Xu
Jun 15, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Longxiao Liu, Xiaocui Wang
May 15, 2007·International Journal of Pharmaceutics·Yousef JavadzadehAli Nokhodchi
Sep 29, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Julia SchniedersThomas Kissel
Jun 23, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Letícia S KoesterValquiria L Bassani
Jan 19, 2012·Drug Development and Industrial Pharmacy·Sachin Kumar SinghDhananjay S Singare
Oct 10, 2013·Drug Development and Industrial Pharmacy·Ayeshah Fateemah Beebee FauzeeRoderick Bryan Walker
Mar 24, 2012·Drug Development and Industrial Pharmacy·Jucimary V SantosLuís A E Batista de Carvalho
Jun 28, 2011·Journal of Pharmaceutical Sciences·Zongming Gao
Jul 30, 2011·Pharmaceutical Development and Technology·Ritesh ShahDinesh Shah
Apr 9, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Miriam HaaserThomas Rades
Jan 1, 2012·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mohammed Amood Al-KamaranyAbdelaziz Bouklouze
Oct 11, 2013·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·K Mohana Raghava SrivalliJ Balasubramaniam
Aug 25, 2012·Pain Research and Treatment·Bing CaiSusanne Bredenberg
Jul 29, 2003·Journal of Pharmaceutical Sciences·Petr Lánský, Michael Weiss
Aug 8, 2008·Drug Development and Industrial Pharmacy·Xiong ZhangRui Yang
Jul 12, 2008·Drug Development and Industrial Pharmacy·Anuradha Adhikary, Pradeep R Vavia
Nov 4, 2009·Pharmaceutical Development and Technology·Mukesh Gohel, Shital H Bariya
Jul 7, 2007·Pharmaceutical Development and Technology·Yousef JavadzadehAli Nokhodchi
May 1, 2010·Pharmaceutical Development and Technology·Solmaz AsnaashariYousef Javadzadeh
Jul 24, 2008·International Journal of Pharmaceutics·Yousef JavadzadehAli Nokhodchi
Aug 23, 2018·Drug Development and Industrial Pharmacy·Sahar Youssef Al-OkbiDina Mahmoud Mostafa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
P Costa, J M Sousa Lobo
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Yongqiang LiXiao Yu Wu
© 2021 Meta ULC. All rights reserved