An Alzheimer's Disease-Derived Biomarker Signature Identifies Parkinson's Disease Patients with Dementia

PloS One
Yosef BerlyandAlice S Chen-Plotkin

Abstract

Biomarkers from multiple modalities have been shown to correlate with cognition in Parkinson's disease (PD) and in Alzheimer's disease (AD). However, the relationships of these markers with each other, and the use of multiple markers in concert to predict an outcome of interest, are areas that are much less explored. Our objectives in this study were (1) to evaluate relationships among 17 biomarkers previously reported to associate with cognition in PD or AD and (2) to test performance of a five-biomarker classifier trained to recognize AD in identifying PD with dementia (PDD). To do this, we evaluated a cross-sectional cohort of PD patients (n = 75) across a spectrum of cognitive abilities. All PD participants had 17 baseline biomarkers from clinical, genetic, biochemical, and imaging modalities measured, and correlations among biomarkers were assessed by Spearman's rho and by hierarchical clustering. We found that internal correlation among all 17 candidate biomarkers was modest, showing a maximum pairwise correlation coefficient of 0.51. However, a five-marker subset panel derived from AD (CSF total tau, CSF phosphorylated tau, CSF amyloid beta 42, APOE genotype, and SPARE-AD imaging score) discriminated cognitively normal P...Continue Reading

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Citations

Aug 17, 2018·Science Translational Medicine·Alice S Chen-PlotkinJing Zhang
Jul 28, 2016·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Ulf AndreassonHenrik Zetterberg
Apr 5, 2020·International Journal of Molecular Sciences·Masaru TanakaLászló Vécsei
Jun 24, 2017·Biomarkers in Medicine·Katrina GwinnLiana S Rosenthal
Nov 24, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas F TropeaAlice S Chen-Plotkin
Jul 6, 2016·Neuroreport·Florence F RoussotteUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay

Software Mentioned

R

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