An Amidochlorin-Based Colorimetric Fluorescent Probe for Selective Cu(2+) Detection

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Wenting LiYingxue Jin

Abstract

The design and synthesis of selective and sensitive chemosensors for the quantification of environmentally and biologically important ionic species has attracted widespread attention. Amidochlorin p6 (ACP); an effective colorimetric and fluorescent probe for copper ions (Cu(2+)) in aqueous solution derived from methyl pheophorbide-a (MPa) was designed and synthesized. A remarkable color change from pale yellow to blue was easily observed by the naked eye upon addition of Cu(2+); and a fluorescence quenching was also determined. The research of fluorescent quenching of ACP-Cu(2+) complexation showed the detection limit was 7.5 × 10(-8) mol/L; which suggested that ACP can act as a high sensitive probe for Cu(2+) and can be used to quantitatively detect low levels of Cu(2+) in aqueous solution. In aqueous solution the probe exhibits excellent selectivity and sensitivity toward Cu(2+) ions over other metal ions (M = Zn(2+); Ni(2+); Ba(2+); Ag⁺; Co(2+); Na⁺; K⁺; Mg(2+); Cd(2+); Pb(2+); Mn(2+); Fe(3+); and Ca(2+)). The obvious change from pale yellow to blue upon the addition of Cu(2+) could make it a suitable "naked eye" indicator for Cu(2+).

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Citations

Aug 26, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Takayo Moriuchi-KawakamiToshiyuki Moriuchi
Aug 26, 2016·Beilstein Journal of Organic Chemistry·Rahman HosseinzadehMaryam Mohadjerani
Jul 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·M A García-SánchezA Arrieta
Apr 13, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Jing XuJiangting Wang
Nov 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yun HuDemeng Sun
May 21, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Tingting ShuYanhua Yu
Jan 7, 2021·Molecular Pharmaceutics·Junior GonzalesThomas Reiner

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Methods Mentioned

BETA
fluorescence titration
Fluorescence

Software Mentioned

Gaussian

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