PMID: 8584436Jan 1, 1996Paper

An ammonium pulse inhibits fluid secretion

Pflügers Archiv : European journal of physiology
K R LauR M Case

Abstract

Exposing perfused mandibular salivary glands to a 5-min pulse of NH4Cl almost totally inhibited fluid secretion evoked by acetylcholine. Recovery from exposure to 0.5 mM NH4Cl occurred within 10 min, but after exposure to 20 mM NH4Cl recovery was not complete even after 30 min. The inhibition could not be explained by changes in intracellular pH as there was no acidosis measurable after the 0.5 mM NH4Cl pulse. NH4Cl did not inhibit intracellular calcium release by acetylcholine so that receptor inhibition could not be the explanation for the inhibition of secretion. These observations indicate that data obtained from ammonium pulse experiments should be interpreted with caution.

References

Jan 1, 1992·Archives of Oral Biology·J C SeagraveJ R Martinez
May 1, 1989·Pflügers Archiv : European journal of physiology·I Novak, J A Young
Apr 1, 1981·Physiological Reviews·A Roos, W F Boron
Jan 1, 1994·The Biochemical Journal·C MichoudetG Baverel

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Citations

Mar 10, 1998·The Journal of Physiology·T Speake, A C Elliott
May 6, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·O BachmannU Seidler

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