PMID: 9534889Apr 16, 1998Paper

An amorphous hydrogel enhances epithelialisation of wounds

Acta Dermato-venereologica
M S Agren

Abstract

Hydrogel dressings are gaining increased clinical acceptance as a wound management modality. The purpose of this study was to compare the effect of three amorphous hydrogels with occlusive, control treatment (Tegaderm) on healing of experimental wounds. Eight partial-thickness cutaneous wounds (2.5 cm x 2.5 cm x 0.04 cm) were made, using an electrokeratome, and the four treatments were allocated by randomisation within a cephalad and a caudal region on each of six 60-kg domestic pigs. In total, twelve wounds were each treated with 2.0 ml of each type of hydrogel--an experimental amorphous hydrogel ("Exgel"), IntraSite Gel and a poloxamer gel containing 3% hydrogen peroxide--and covered with Tegaderm, or treated with Tegaderm alone. At 66 h post-operatively, formalin-fixed, paraffin-embedded sections of wounds were hematoxylin-eosin-stained and assessed morphometrically for epithelium coverage in a blinded fashion. The Exgel remained macroscopically intact on the wounds in contrast to the other hydrogels, which had dissolved completely after treatment. Exgel significantly (p < 0.05) increased epithelial coverage of the wounds, compared with the other treatments (by 20% more than Tegaderm-treated wounds). In vitro experiments ind...Continue Reading

Citations

Mar 19, 2002·Advanced Drug Delivery Reviews·Alexander V KabanovValery Alakhov
Jan 22, 2003·Advanced Drug Delivery Reviews·Alexander V KabanovDonald W Miller
May 16, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·F GottrupT Karlsmark
Jul 27, 2004·The Journal of Burn Care & Rehabilitation·K R KirkerG D Prestwich
Jun 15, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stefan BeckertStephan Coerper
Oct 1, 2009·Acta Biomaterialia·E A Torres VargasA A A de Queiroz
May 26, 2006·International Wound Journal·Douglas QueenGeoff Sussman
Nov 17, 2006·Journal of Biomedical Materials Research. Part a·Ankit AgarwalSurya K Mallapragada
Apr 28, 2011·Journal of Biomedical Materials Research. Part a·Huanan LiXingdong Zhang
Jan 13, 2006·Biochimica Et Biophysica Acta·Artem E ZhirnovNickolay S Melik-Nubarov
Aug 27, 2016·Carbohydrate Polymers·Ram Sarup SinghJohn F Kennedy
Mar 27, 2013·Phlebology·G Mosti
May 29, 2003·AORN Journal·Virginia A Capasso, Barbara Hazard Munro
Feb 15, 2019·Pharmaceutics·Dinis MateusAntónio J Almeida
Aug 28, 2019·Pharmaceutics·Anca OnaciuIoana Berindan-Neagoe
Oct 10, 2003·Journal of Biomaterials Science. Polymer Edition·M J GimenoJ Buján

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.