An amylin analog used as a challenge test for Alzheimer's disease

Alzheimer's & Dementia : Translational Research & Clinical Interventions
Haihao ZhuWei Qiao Qiu

Abstract

Preclinical studies demonstrate the potential of amylin in the diagnosis of Alzheimer's disease (AD). We aimed to lay the foundation for repurposing the amylin analog and a diabetes drug, pramlintide, for AD in humans. We administered a single subcutaneous injection of 60 μg of pramlintide to nondiabetic subjects under fasting conditions. None of the participants developed hypoglycemia after the injection of pramlintide. The pramlintide challenge induced a significant surge of amyloid-β peptide and a decrease in total tau in the plasma of AD subjects but not in control participants. The pramlintide injection provoked an increase in interleukin 1 receptor antagonist and a decrease in retinol-binding protein 4, which separates AD subjects from control subjects. Pramlintide use appeared to be safe in the absence of diabetes. The biomarker changes as a result of the pramlintide challenge, which distinguished AD from control subjects and mild cognitive impairment.

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Aug 21, 2019·Journal of Molecular Modeling·Nelson A AlvesRafael B Frigori
Feb 8, 2018·Journal of Oncology Practice·Bobby DalyLinda D Bosserman
Jul 25, 2019·Current Drug Targets·Ammu Prasanna KumarSuryani Lukman
Feb 27, 2018·Journal of Alzheimer's Disease : JAD·Qiushan TaoUNKNOWN Alzheimer’s Disease Metabolomics Consortium
Jul 14, 2019·Clinical Epigenetics·Yorick JanssensBart De Spiegeleer
Sep 15, 2017·Physical Chemistry Chemical Physics : PCCP·Rafael B Frigori
Dec 14, 2017·Neuropharmacology·Elizabeth G Mietlicki-Baase

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Methods Mentioned

BETA
blood draws
blood draw
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

ROCR
Google search
SAS
R Foundation for Statistical Computing

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