An amyloid-forming segment of beta2-microglobulin suggests a molecular model for the fibril

Proceedings of the National Academy of Sciences of the United States of America
Magdalena I IvanovaDavid Eisenberg

Abstract

In humans suffering from dialysis-related amyloidosis, the protein beta2-microglobulin (beta2M) is deposited as an amyloid; however, an amyloid of beta2M is unknown in mice. beta2M sequences from human and mouse are 70% identical, but there is a seven-residue peptide in which six residues differ. This peptide from human beta2M forms amyloid in vitro, whereas the mouse peptide does not. Substitution of the human peptide for its counterpart in the mouse sequence results in the formation of amyloid in vitro. These results show that a seven-residue segment of human beta2M is sufficient to convert beta2M to the amyloid state, and that specific residue interactions are crucial to the conversion. These observations are consistent with a proposed Zipper-spine model for beta2M amyloid, in which the spine of the fibril consists of an anhydrous beta-sheet.

References

Nov 1, 1968·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·E D Eanes, G G Glenner
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F TagliaviniG Forloni
Nov 14, 1997·Journal of Molecular Biology·M SundeC C Blake
Nov 18, 1997·European Journal of Biochemistry·M StoppiniG Ferri
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·T L BenzingerS C Meredith
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·E H KooJ W Kelly
Sep 2, 1999·Trends in Biochemical Sciences·C M Dobson
Feb 27, 2001·Nature Structural Biology·Y LiuD Eisenberg
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·M BalbirnieD S Eisenberg
Mar 10, 2001·Nature·M FändrichC M Dobson
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·M F PerutzA Lesk
Apr 23, 2002·Nature Structural Biology·Victoria J McParlandSheena E Radford
Apr 23, 2002·Nature Structural Biology·Masaru HoshinoYuji Goto
Jul 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·José L JiménezHelen R Saibil
Jul 4, 2002·The Journal of Biological Chemistry·Meital RechesEhud Gazit
Aug 21, 2002·Biochemistry·Catherine M EakinAndrew D Miranker
Nov 1, 2002·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Per WestermarkJean D Sipe
Nov 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Manuela López De La PazLuis Serrano
Dec 19, 2002·Journal of Molecular Biology·Susan JonesSheena E Radford
May 20, 2003·Nature Structural Biology·Jennifer Stine ElamP John Hart
Jul 16, 2003·Journal of Molecular Biology·Ruben Diaz-AvalosDonald L D Caspar
Nov 19, 2003·Biochemistry·Magdalena I IvanovaDavid Eisenberg
Dec 23, 2003·Journal of Molecular Biology·Angela D WilliamsRonald Wetzel
Jan 1, 1952·Advances in Protein Chemistry·K M RUDALL
Feb 21, 2004·Biochemical and Biophysical Research Communications·Aiko KishimotoMasasuke Yoshida

❮ Previous
Next ❯

Citations

Oct 19, 2005·Journal of Molecular Modeling·Aswin Sai Narain SeshasayeeGautam Pennathur
Sep 20, 2006·Accounts of Chemical Research·David EisenbergChristian Riekel
Jul 29, 2010·Journal of the American Chemical Society·Galia T DebelouchinaRobert G Griffin
Apr 29, 2011·Journal of the American Chemical Society·Melissa PauliteGilbert C Walker
Jan 21, 2010·Journal of the American Chemical Society·Jorge Pedro López-AlonsoDouglas V Laurents
Jun 10, 2005·Nature·Rebecca NelsonDavid Eisenberg
Jan 28, 2009·Nature Structural & Molecular Biology·Matthew F CalabreseAndrew D Miranker
Dec 7, 2010·Nature Structural & Molecular Biology·Cong LiuDavid Eisenberg
Nov 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Bo MaoChen Wang
Feb 2, 2012·Journal of Biomolecular Structure & Dynamics·Josephine W Wu, Hsuan-Liang Liu
May 11, 2012·Journal of Biomolecular Structure & Dynamics·Yuanyuan YuYoutao Song
Dec 19, 2009·Bioinformatics·Sergiy O GarbuzynskiyOxana V Galzitskaya
Sep 4, 2013·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Yanlian Yang, Chen Wang
Nov 8, 2006·Molekuliarnaia biologiia·O V GalzitskaiaM Iu Lobanov
Jul 5, 2006·Journal of Bioinformatics and Computational Biology·Oxana V GalzitskayaMichail Yu Lobanov
Feb 28, 2007·BMC Bioinformatics·Oscar Conchillo-SoléSalvador Ventura
Oct 4, 2005·BMC Structural Biology·Natalia Sánchez de GrootSalvador Ventura
Aug 22, 2009·PLoS Computational Biology·Virginia Castillo, Salvador Ventura
Nov 5, 2010·PloS One·Anna Villar-PiquéSalvador Ventura
Jul 25, 2008·Future Microbiology·Natalia S de GrootSalvador Ventura
Jul 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ruben Diaz-AvalosDonald L D Caspar
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael J ThompsonDavid Eisenberg
Nov 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Alexandra Esteras-ChopoManuela López de la Paz
Jun 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Anna Nordlund, Mikael Oliveberg
Apr 14, 2012·Bioorganicheskaia khimiia·A V DanilkovichI P Udovichenko
Aug 21, 2010·Prion·Alexey V KrasnoslobodtsevYuri L Lyubchenko
May 9, 2012·Prion·Natallia Makarava, Ilia V Baskakov
Apr 28, 2016·Journal of the American Chemical Society·Theodoros K KaramanosSheena E Radford
Jan 25, 2011·Molecular Cell·Timo EichnerSheena E Radford
Jun 8, 2011·Journal of Molecular Biology·Raffaela Cabriolu, Stefan Auer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Salvador VenturaLuis Serrano
Proceedings of the National Academy of Sciences of the United States of America
Magdalena I IvanovaDavid Eisenberg
© 2022 Meta ULC. All rights reserved