An analysis of 17 catatonic patients diagnosed with neuroleptic malignant syndrome

CNS Spectrums
D A White, A H Robins

Abstract

This study was conducted to show that catatonia is a predisposing factor for neuroleptic malignant syndrome (NMS) and to review the nosological relationship between catatonia and NMS. Seventeen consecutive cases of NMS were analyzed prospectively with reference to clinical and investigative findings before and after exposure to a neuroleptic. The series comprised eight males and nine females, ranging in age from 18 years to 65 years. Prior to neuroleptic exposure, all patients exhibited features compatible with criteria for catatonia (mutism/excitement) according to the Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised, (DSM-III-R). Following neuroleptic administration (single dose in nine cases), patients deteriorated into a febrile, rigid, and obtunded state accompanied by autonomic dysfunction and raised creatine phosphokinase levels. These features were consistent with a diagnosis of NMS. Neuroleptics were discontinued and supportive medical treatment instituted. Benzodiazepines were beneficial in eight cases in relieving stupor, but bromocriptine and dantrolene were generally ineffective. In all patients diagnosed with NMS in the authors' series, catatonia was an invariable prodromal state. It ap...Continue Reading

References

May 1, 1976·Archives of General Psychiatry·R Abrams, M A Taylor
Oct 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·D A White
Mar 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·D A White, A H Robins
Jan 1, 1990·Acta Psychiatrica Scandinavica·W W FleischhackerH Hinterhuber
Jun 1, 1989·The American Journal of Psychiatry·P Rosebush, T Stewart
Oct 1, 1989·Archives of General Psychiatry·P E KeckA A Nierenberg
Dec 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·D K PriceD G Stevens
Mar 1, 1989·The American Journal of Psychiatry·E CastilloE Holsboer-Trachsler
Mar 1, 1985·Biological Psychiatry·G L Fricchione
Aug 1, 1987·Biological Psychiatry·G AddonizioS D Roth
Jun 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·A M Kellam
Sep 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·M P BarnesC A Kirk
Nov 1, 1986·The American Journal of Psychiatry·S C MannM Hayashida
Nov 1, 1981·Psychological Medicine·B Mahendra
Oct 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·A A Osman, M H Khurasani
Jan 1, 1994·The Journal of Neuropsychiatry and Clinical Neurosciences·K L Philbrick, T A Rummans
Apr 1, 1994·Acta Psychiatrica Scandinavica·G S UngvariJ Lau
Jun 1, 1997·Journal of Clinical Psychopharmacology·B T Carroll, R E Taylor
Jan 26, 2000·Comprehensive Psychiatry·M KochA Francis

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Citations

Mar 11, 2008·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Sherese AliGregory L Fricchione
Sep 25, 2015·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Jacqui KaelleMatthew D Macfarlane
Jan 13, 2017·World Journal of Psychiatry·Sean A RasmussenPatricia I Rosebush
Apr 29, 2010·Current Psychiatry Reports·Andrew Francis
Apr 30, 2014·Neuropsychiatry·Nancy Kerner, Joan Prudic
Feb 19, 2020·International Review of Psychiatry·Charles Mormando, Andrew Francis
Nov 20, 2014·Psychopharmacology·Fabian U LangMarkus Jäger

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