PMID: 1203855Dec 1, 1975Paper

An analysis of a multiple-drug program in the treatment of patients with advanced breast cancer utilizing 5-fluorouracil, cyclophosphamide, and prednisone with or without vincristine

Cancer
D L AhmannW F Taylor

Abstract

Ninety patients with advanced breast cancer received a polychemotherapeutic program composed of 5-fluorouracil, cyclophosphamide, and prednisone with or without vincristine as a control group in a series of four consecutive Phase II clinical trials of new drug programs. Objective regression rates were 59% without vincristine and 46% with vincristine. Projected mean length of regressions exceeds 1 year. Site of dominant disease, disease-free interval, or performance scale score (if score was 0, 1, or 2, ECOG scale) failed to influence response rates; decreasing response rates were noted as the length of time increased after menopause. No advantage existed in patients experiencing severe myelosuppression (nadir leukocyte count of less than 1,500/mm), and appreciable response rates occurred without significant myelosuppression. The addition of vincristine to the regimen failed to increase the response rates, and only increased toxicity. The program as outlined is reasonably tolerable and effective for this group of patients with advanced breast cancer.

References

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Citations

Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·R MörzK Moser
Jan 10, 1980·The New England Journal of Medicine·I C Henderson, G P Canellos
Jan 1, 1987·Acta Oncologica·S Gundersen, S Kvinnsland
Dec 1, 1987·Cancer Treatment Reviews·K PossingerW Wilmanns
Apr 1, 1981·The American Journal of Medicine·R B WeissV T DeVita
Apr 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P ValagussaG Bonadonna
Jul 1, 1980·Clinical Radiology·B HancockP M Wilkinson
Jul 1, 1980·American Journal of Surgery·H S MoseleyW S Fletcher
Nov 12, 2010·The Cochrane Database of Systematic Reviews·Daria J ButtersPeter T Mallon
Feb 9, 2012·The Australasian Journal of Dermatology·Sarah ShenChristopher J McCormack
Aug 13, 2014·World Journal of Clinical Oncology·Jennifer A CrozierAlvaro Moreno-Aspitia
Jun 26, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jessica M ScottLee W Jones
Nov 1, 1976·The Australian and New Zealand Journal of Surgery·E L Cant
Jan 1, 1984·Medical Oncology and Tumor Pharmacotherapy·L S Perlow, J F Holland

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