An analysis of aging-related genes derived from the Genotype-Tissue Expression project (GTEx)

Cell Death Discovery
Kaiwen JiaQinghua Cui

Abstract

Aging is a complex biological process that is far from being completely understood. Analyzing transcriptional differences across age might help uncover genetic bases of aging. In this study, 1573 differentially expressed genes, related to chronological age, from the Genotype-Tissue Expression (GTEx) project, were categorized as upregulated age-associated genes (UAGs) and downregulated age-associated genes (DAGs). Characteristics in evolution, expression, function and molecular networks were comprehensively described and compared for UAGs, DAGs and other genes. Analyses revealed that UAGs are more clustered, more quickly evolving, more tissue specific and have accumulated more single-nucleotide polymorphisms (SNPs) and disease genes than DAGs. DAGs were found with a lower evolutionary rate, higher expression level, greater homologous gene number, smaller phyletic age and earlier expression in body development. UAGs are more likely to be located in the extracellular region and to occur in both immune-relevant processes and cancer-related pathways. By contrast, DAGs are more likely to be located intracellularly and to be enriched in catabolic and metabolic processes. Moreover, DAGs are also critical in a protein-protein interactio...Continue Reading

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Citations

Mar 12, 2020·Human Molecular Genetics·Silke SzymczakAlmut Nebel
Nov 7, 2019·Genome Biology·Brunilda BalliuStephen B Montgomery
May 13, 2021·Nature Communications·Changde Cheng, Mark Kirkpatrick
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Jul 27, 2021·Computational and Structural Biotechnology Journal·Daniele MercatelliPietro Hiram Guzzi

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Methods Mentioned

BETA
RNA-Seq

Software Mentioned

Cytoscape
NetworkX
Ensembl
DAVID
GTEx

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