PMID: 3748784Aug 1, 1986Paper

An analysis of glomerular-tubular balance in the rat proximal tubule

Pflügers Archiv : European journal of physiology
O W PetersonR C Blantz

Abstract

An analysis of glomerulo-tubular balance in the rat proximal tubule. Flow dependence of absolute proximal reabsorption (APR) or glomerulo-tubular balance (GTB) has been observed with spontaneous alterations in flow and attributed to both intraluminal and extraluminal factors. Flow dependent alterations in APR were demonstrated when 1. nephron filtration rate (SNGFR) was decreased by tubulo-glomerular feedback mechanisms by increasing late proximal tubular microperfusion rates, and 2. when SNGFR was increased by addition of [Sar1, Ala8] angiotensin II to the adjacent peritubular capillary flow. Selective reduction in early proximal tubular flow rate by pump aspiration also resulted in flow dependent reductions in APR. However, selective additions of perfusion fluids of various native and artificial constituency to the early proximal tubule did not result in flow dependent increase in APR. Conclusions. 1. GTB with both increases and decreases in SNGFR can be demonstrated at the level of the single nephron, 2. selective reductions in luminal flow rate produces parallel reductions in APR; however, 3. increases in flow rate with either artificial or native fluids of different ionic concentrations did not result in increases in APR. ...Continue Reading

References

Aug 1, 1979·The Journal of Clinical Investigation·R W SteinerR C Blantz
Feb 1, 1976·The Journal of Clinical Investigation·R C BlantzB J Tucker
Sep 1, 1968·The Journal of Clinical Investigation·M B Burg, J Orloff
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Jul 1, 1981·Kidney International·D A HäberleJ M Davis

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Citations

Aug 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zhaopeng DuTong Wang
Nov 1, 1990·Kidney International·M SteinhausenD L Wiegman
Mar 24, 2017·Antioxidants·Agustin Gonzalez-Vicente, Jeffrey L Garvin
Oct 3, 2002·The American Journal of Gastroenterology·G SansoèM Rizzetto
Oct 2, 2014·Journal of the American Society of Nephrology : JASN·Marcus PohlFranziska Theilig
Sep 8, 2005·American Journal of Physiology. Renal Physiology·Zhaopeng DuTong Wang
Jan 11, 2007·American Journal of Physiology. Renal Physiology·Alan M WeinsteinTong Wang
May 6, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Peter J HarrisS Randall Thomas
Jul 16, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Anita T Layton
Apr 5, 2003·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Larry A SlomowitzScott C Thomson
Feb 26, 2019·PLoS Computational Biology·Anita T Layton, Harold E Layton
Sep 21, 2000·American Journal of Physiology. Renal Physiology·P GuoS Weinbaum
Mar 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mario RuizFrancis B Gabbai
Feb 14, 1998·Kidney International·R C Blantz
Oct 1, 1990·Kidney International·R C BlantzF B Gabbai

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