An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment.

Cancer
Sarah B FisherShishir K Maithel

Abstract

Tumor overexpression of excision repair cross-complementing gene-1 (ERCC1) may be associated with decreased survival in patients with pancreas adenocarcinoma (PAC). Human equilibrative nucleoside transporter-1 (hENT1) and ribonucleoside reductase subunits M1 and M2 (RRM1 and RRM2) are integral to cellular transport and DNA synthesis and are implicated as poor prognostic factors in other malignancies. To the authors's knowledge, their role in PAC is not defined. A prospective database was used to randomly select 95 patients who underwent pancreaticoduodenectomy for PAC between January 2000 and October 2008. Immunohistochemical analysis was performed on tumor samples for hENT1, RRM1 and RRM2, and ERCC1. Main outcomes were recurrence-free survival (RFS) and overall survival (OS). The median follow-up, RFS, and OS were 49 months, 10.6 months, and 15.5 months, respectively. The median tumor size was 3 cm. Approximately 26% of patients had positive microscopic margins, 61% had lymph node involvement, and 88% and 45% had perineural and lymphovascular invasion, respectively. High tumor expression of hENT1, RRM1, RRM2, and ERCC1 was present in 85%, 40%, 17%, and 16%, respectively, of patients. High hENT1 expression was associated with r...Continue Reading

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Citations

Dec 5, 2013·Journal of the National Cancer Institute·William GreenhalfUNKNOWN European Study Group for Pancreatic Cancer
Aug 3, 2013·Biomarkers in Medicine·Lars Petter Jordheim, Charles Dumontet
Dec 2, 2014·Archives of Pathology & Laboratory Medicine·Mary M ZutterSophia L Yohe
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Jun-Feng ZhangJiao Li
Oct 3, 2013·Expert Opinion on Therapeutic Targets·Jimin ShaoYun Yen
Aug 1, 2015·Hematology/oncology Clinics of North America·Lingling DuAndrea Wang-Gillam
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Oct 18, 2016·Pancreas·James J FarrellHany Elsaleh
Apr 18, 2019·Current Opinion in Oncology·Thierry Conroy, Michel Ducreux
Jun 18, 2021·Indian Journal of Pathology & Microbiology·Khushbu KhetanPrasenjit Das

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