An analysis of human sperm chromosome aneuploidy

Cytogenetics and Cell Genetics
C TempladoA M Estop

Abstract

A sperm chromosome analysis of 24 men with normal or balanced karyotypes was carried out to study the frequency of sperm chromosome aneuploidy. A total of 3,446 human sperm complements (36-315 per donor) was analyzed after in vitro penetration of hamster eggs. Two sets of donors were studied at two different centers in the United States (center 1) and Spain (center 2). The frequencies of hyperhaploidy and hypohaploidy in control donors were similar between center 1 (1.9% vs. 7.7%) and center 2 (1.8% vs. 10.3%). In carrier donors there were no significant differences between the two centers in the frequency of hyperhaploidy (0.8% vs. 1.9%), but that of hypohaploidy was significantly higher in center 2 (11.0%) than in center 1 (4.6%). A significant excess of hypohaploid complements, as compared to hyperhaploid complements, was found in both centers in both control and carrier donors. The sex ratio was similar in both centers and did not differ significantly from a 1:1 sex ratio. The larger chromosomes in the complement (1, 2, 3, 4, 5, 7, and 10) presented a significantly lower frequency of hypohaploidy, while some of the smaller chromosomes (13, 19, and 21) showed a higher frequency of hypohaploidy than expected. Chromosome 21 an...Continue Reading

Citations

Sep 24, 2004·Gynécologie, obstétrique & fertilité·N RivesB Macé
Jun 13, 2003·Fertility and Sterility·Renée H MartinAlfred W Rademaker
Jan 1, 1999·Maturitas·U Eichenlaub-Ritter
Jun 7, 2008·Human Reproduction Update·R H Martin
Jul 27, 2011·Therapeutic Advances in Urology·Kathleen HwangDolores J Lamb
Sep 3, 2013·Fertility and Sterility·Jeremy T Choy, Robert E Brannigan
Feb 2, 2011·Cytogenetic and Genome Research·C TempladoA Estop
Jan 8, 2011·Cytogenetic and Genome Research·K G L Fonseka, D K Griffin
Aug 23, 2018·Andrologia·Sezgin GunesRalf Henkel
Jul 21, 2001·European Journal of Human Genetics : EJHG·M BoschC Templado
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Sep 30, 2005·Cytogenetic and Genome Research·C TempladoJ Benet
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May 31, 2013·Molecular Human Reproduction·C TempladoA Estop
Jul 1, 2021·Molecular Human Reproduction·Nicoletta TarozziAndrea Borini
Apr 17, 2008·Reproductive Biomedicine Online·Renée H Martin

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