An analysis of inhibitory functioning in individuals with chronic posttraumatic stress disorder

Journal of Anxiety Disorders
Aileen M Echiverri-CohenJawad Husain


Cognitive abnormalities in posttraumatic stress disorder (PTSD) may be a function of underlying inhibitory deficits. Prepulse inhibition (PPI) and attentional blink (AB) are paradigms thought to assess inhibition. Using a sample of 28 individuals with PTSD compared to 20 trauma-exposed and 19 healthy individuals, PPI was examined using white noise that was preceded by a tone, and AB was examined using a presentation of letters in a stream of numbers. Relative to the control group, the PTSD and trauma-exposed groups did not follow the u-shaped pattern in AB, suggesting trauma-exposure and subsequent PTSD are associated with similar impairment in attention. Individuals with PTSD showed reduced PPI compared to trauma-exposed and healthy individuals, suggesting individuals with PTSD exhibit faulty automatic processing. For individuals with PTSD, PTSD severity was associated with a decline in PPI. These findings suggest a general faulty inhibitory mechanism associated with trauma exposure and PTSD.


Jul 1, 1989·The American Journal of Psychiatry·E M Ornitz, R S Pynoos
Aug 1, 1987·The American Journal of Psychiatry·L C Kolb
Nov 6, 1987·Science·E Weichselgartner, G Sperling
Dec 1, 1986·The Journal of Nervous and Mental Disease·E M Bernstein, F W Putnam
Apr 1, 1973·Journal of Consulting and Clinical Psychology·S M Auerbach
Dec 1, 1995·Archives of General Psychiatry·R C KesslerC B Nelson
Feb 1, 1995·Journal of Experimental Psychology. Human Perception and Performance·M M Chun, M C Potter
May 1, 1995·Behaviour Research and Therapy·M CreamerR Bell
Jan 1, 1993·Psychopharmacology·H S Koelega
Jul 1, 1994·Comprehensive Psychiatry·D L SegalV B Van Hasselt
Sep 1, 1993·Biological Psychiatry·A C McFarlaneC R Clark
Feb 1, 1993·The American Journal of Psychiatry·J Douglas BremnerDennis S Charney
Feb 14, 1998·Neuropsychology·J J VasterlingP B Sutker
Jul 24, 1998·Psychopharmacology·V Della CasaJ Feldon
Jul 31, 1998·Behaviour Research and Therapy·P J BielingR P Swinson
Feb 2, 1999·The British Journal of Psychiatry : the Journal of Mental Science·R F MollicaS Tor
Apr 15, 1999·Biological Psychiatry·J Douglas Bremner
Jun 15, 1999·Psychosomatic Medicine·Murray B SteinC D Sherbourne
Aug 27, 1999·Progress in Neurobiology·M Koch
Mar 1, 2000·The Journal of General Psychology·M S Peterson, J F Juola
May 29, 2000·Trends in Cognitive Sciences·G BushM I Posner
Jan 11, 2000·Journal of Traumatic Stress·PTSD Treatment Guidelines Task Force
Feb 13, 2001·Brain and Cognition·K C KoenenL Schlesinger
Dec 26, 2001·Biological Psychiatry·L M ShinS L Rauch
Jul 26, 2002·The Psychiatric Clinics of North America·Julia Golier, Rachel Yehuda
Aug 13, 2002·Annual Review of Psychology·Richard J McNally
Oct 16, 2002·Nature Neuroscience·Mark W GilbertsonRoger K Pitman
Mar 5, 2003·Psychonomic Bulletin & Review·Edward K Vogel, Steven J Luck
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Mar 6, 2004·Annals of the New York Academy of Sciences·Barbara Olasov Rothbaum, Michael Davis
Mar 23, 2004·Psychophysiology·Jonathan K WynnAnne M Schell
Mar 23, 2004·Psychophysiology·Terry D BlumenthalMagne Arve Flaten
Apr 23, 2004·Psychophysiology·Tanja JovanovicErica J Duncan
May 5, 2004·Journal of Abnormal Psychology·Chiang-shan Ray LiYa-wen Hung
Sep 25, 2004·The Journal of Nervous and Mental Disease·Timo GiesbrechtEllen Smeets
Nov 24, 2004·Trends in Cognitive Sciences·Matthew M BotvinickCameron S Carter
Feb 22, 2005·Psychophysiology·Terry D BlumenthalAnton van Boxtel
Jun 18, 2005·NeuroImage·Klaus KesslerAlfons Schnitzler
Jul 22, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Deborah S LipschitzSteven M Southwick
Aug 13, 2005·Neuroscience and Biobehavioral Reviews·Vinuta RauMichael S Fanselow
Mar 16, 2006·Cognitive Neuropsychiatry·Wissam El-HageCatherine Belzung
Aug 8, 2006·Journal of Psychiatric Research·Jonathan K WynnMichael F Green
Aug 30, 2006·Journal of Anxiety Disorders·Pushpa Kanagaratnam, Arve E Asbjørnsen
Sep 13, 2006·Psychophysiology·Brian R CornwellChristian Grillon
Nov 2, 2007·Psychonomic Bulletin & Review·Paul E Dux, Irina M Harris
Oct 16, 2008·Addiction Biology·David E Evans, David J Drobes
Feb 26, 2011·Neuropharmacology·Robin L AupperleMartin P Paulus
Aug 24, 2011·Emotion·Nicholas T Van DamJeanette Altarriba
Jan 5, 2013·Journal of Psychiatric Research·S KohlJ Kuhn
Mar 10, 2015·Behavioural Brain Research·Sophie A GeorgeIsrael Liberzon
Jun 2, 2015·Frontiers in Human Neuroscience·Brandon L AldermanTracey J Shors


Feb 7, 2019·Behavioural Pharmacology·Simona CabibStefano Puglisi Allegra
Sep 19, 2018·Neuropharmacology·Georgina Perez-GarciaGregory A Elder

Related Concepts

Mental Concentration
Chronic Disease
Psychological Inhibition
Noise Pollution
Startle Reaction
Delayed Onset Post-Traumatic Stress Disorder
Nested Case-Control Studies
Attentional Blink

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.