An analysis of inhibitory functioning in individuals with chronic posttraumatic stress disorder

Journal of Anxiety Disorders
Aileen M Echiverri-CohenJawad Husain

Abstract

Cognitive abnormalities in posttraumatic stress disorder (PTSD) may be a function of underlying inhibitory deficits. Prepulse inhibition (PPI) and attentional blink (AB) are paradigms thought to assess inhibition. Using a sample of 28 individuals with PTSD compared to 20 trauma-exposed and 19 healthy individuals, PPI was examined using white noise that was preceded by a tone, and AB was examined using a presentation of letters in a stream of numbers. Relative to the control group, the PTSD and trauma-exposed groups did not follow the u-shaped pattern in AB, suggesting trauma-exposure and subsequent PTSD are associated with similar impairment in attention. Individuals with PTSD showed reduced PPI compared to trauma-exposed and healthy individuals, suggesting individuals with PTSD exhibit faulty automatic processing. For individuals with PTSD, PTSD severity was associated with a decline in PPI. These findings suggest a general faulty inhibitory mechanism associated with trauma exposure and PTSD.

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Citations

Feb 7, 2019·Behavioural Pharmacology·Simona CabibStefano Puglisi Allegra
Sep 19, 2018·Neuropharmacology·Georgina Perez-GarciaGregory A Elder

Related Concepts

Mental Concentration
Chronic Disease
Psychological Inhibition
Noise Pollution
Startle Reaction
Delayed Onset Post-Traumatic Stress Disorder
Nested Case-Control Studies
Attentional Blink
Self-Report
Attention

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