An analysis of lamellar x-ray diffraction from disordered membrane multilayers with application to data from retinal rod outer segments

Biophysical Journal
S SchwartzJ K Blasie

Abstract

Oriented multilayers containing a membrane pair within the unit cell potentially possess both lattice disorder and substitution disorder. Lattice disorder occurs when there is a lack of long-range order in the lattice spacings produced by a variation in the nearest neighbor distances between unit cells. A simple form of substitution disorder can arise from a variation in the separation of the two membranes within the unit cells in the multilayer. Lattice disorder produces a monotonically increasing width for higher order lamellar "reflections" while simple substitution disorder produces an incoherent intensity underlying the coherent intensity. A generalized Patterson function analysis has been developed for treating lamellar diffraction from lattice disordered multilayers. This analysis allows the identification of the autocorrelation function of the unit cell electron density profile and its subsequent deconvolution to provide the unit cell electron density profile. A recursive procedure has been developed for separating the incoherent intensity from the coherent intensity via a Gaussian probability model of the membrane intra-pair separation. In cases studied so far both disorders can be quantitatively accounted for and elim...Continue Reading

Citations

Feb 15, 1981·The Journal of Membrane Biology·G Büldt, R Wohlgemuth
Jan 1, 1985·The Journal of Membrane Biology·J K BlasieJ Pachence
Jan 1, 1986·Vision Research·M L Applebury, P A Hargrave
Nov 7, 2000·Biochimica Et Biophysica Acta·J F Nagle, S Tristram-Nagle
Jun 21, 2012·Journal of Synchrotron Radiation·Naoto YagiNoboru Ohta
Jan 12, 2016·Journal of Colloid and Interface Science·Ana Maria Percebom, Watson Loh
Jan 1, 1980·Progress in Histochemistry and Cytochemistry·J M Corless
Sep 1, 1976·Experimental Eye Research·J M CorlessJ D Robertson
Jun 25, 1984·Journal of Molecular Biology·E F EikenberryB Brodsky
Apr 1, 1979·Photochemistry and Photobiology·E A DratzS Schwartz
Jul 1, 1977·Photochemistry and Photobiology·W L Stone, E A Dratz
May 26, 2017·PLoS Biology·Jonathan D NickelsJohn Katsaras
Mar 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Pengfei ZhangEdward N Pugh
Jan 11, 1978·Biochimica Et Biophysica Acta·J K BlasieJ S Leigh
Sep 25, 1976·Journal of Molecular Biology·A E Blaurock, W Wober
Jul 26, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Sofiya MatviykivBert Müller

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