An analysis of measured and estimated creatinine clearance rates in normal weight, overweight, and obese patients with gynecologic cancers

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Wendelin K NelsonThomas J Rutherford

Abstract

Different equations used to estimate creatinine clearance (Cl(cr)) in obese oncology patients can produce divergent estimated creatinine clearance values, which in turn can result in significantly different calculated carboplatin doses. Standardization of the calculation of creatinine clearance in patients of all body types is a desirable goal. The objective of our study was to examine the impact of increasing body mass index on the accuracy of creatinine clearance estimation methods and to determine the optimal equation for creatinine clearance estimation in the obese adult female cancer patient. Retrospective data analysis. We compared the estimated creatinine clearance values produced by each of 11 equations to 24-hour creatinine clearance values measured in 119 adult female patients with gynecologic cancers grouped according to body composition. We applied simple linear regression and Tukey mean-difference analysis to assess the relationship between estimated creatinine clearance values produced by these equations and measured creatinine clearance values for each patient. The relationship between measured creatinine clearance and estimated creatinine clearance produced by all equations displayed lower linear regression R (2...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Nov 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A H CalvertE Wiltshaw
Jun 1, 1988·The American Journal of Medicine·D E Salazar, G B Corcoran
Oct 1, 1973·Annals of Internal Medicine·R W Jelliffe
Oct 1, 1995·Hypertension·J RibsteinA Mimran
Apr 19, 1995·Journal of the National Cancer Institute·E ChatelutR Bugat
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·L J van WarmerdamJ H Beijnen
Jun 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S BénézetP Canal
Sep 12, 2000·The Annals of Pharmacotherapy·M P Pai, F P Paloucek
Dec 29, 2000·Therapeutic Drug Monitoring·M J MontgomeryM A Gill
Feb 24, 2001·British Journal of Cancer·J G WrightA H Calvert
Dec 26, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J DooleyL K Webster
Aug 15, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A FeliciA Sparreboom
May 23, 2003·Journal of the American Society of Nephrology : JASN·Avry ChagnacYaacov Ori
Feb 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G M MarxP G Harper
Aug 3, 2004·Nature Reviews. Cancer·Eugenia E Calle, Rudolf Kaaks
Jul 14, 2005·Journal of Cancer Research and Clinical Oncology·Karin HolwegerHans-Peter Lipp
Sep 24, 2005·Clinical Pharmacokinetics·Sarayut JanmahasatianBruce Green
Jan 9, 2007·Transfusion·Mohamad KassarDennis L Cooper
Oct 24, 2007·Clinical Pharmacology and Therapeutics·P Y HanB Green
Apr 15, 2008·Gynecologic Oncology·Jason D WrightMatthew A Powell
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A BookmanLawrence M Roth
Mar 21, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jasmina A DemirovicManjunath P Pai
Mar 13, 2010·Gynecologic Oncology·Don S Dizon
Jul 27, 2010·Pharmacotherapy·Thomas C DowlingGilbert J Burckart

❮ Previous
Next ❯

Citations

May 11, 2015·Gynecologic Oncology·Jean HansenMichael J Goodheart
Jan 23, 2018·Clinical Pharmacokinetics·Laura A Hart, Gail D Anderson
Sep 5, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Cristina Cuesta GruesoMaría S Díaz Carrasco
Jan 10, 2020·Cancer Chemotherapy and Pharmacology·Melanie White-KoningFlorent Puisset
Feb 8, 2020·Therapeutic Advances in Endocrinology and Metabolism·Marcus MayStefan Engeli

❮ Previous
Next ❯

Methods Mentioned

BETA
urine collections
urine sample collection

Software Mentioned

R
Excel
ggplot2

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved