An analysis of MYC and EBV in diffuse large B-cell lymphomas associated with angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma not otherwise specified

Human Pathology
Jenny C HoffmannRobert S Ohgami

Abstract

Composite diffuse large B-cell lymphomas (DLBCLs) with peripheral T-cell lymphomas (PTCLs) are rare co-occurrences with poorly understood pathologic features. Herein, we describe 15 distinct cases of DLBCL occurring in association with PTCL, including angioimmunoblastic T-cell lymphoma (AITL; n = 12) and PTCL, not otherwise specified (n = 3). Sheets of large B cells were seen in all cases, with Hodgkin/Reed-Sternberg-like (HRS-L) cells present in 6 cases. When compared to cases of AITL without DLBCL, HRS-L cells were more frequently seen in cases of AITL with DLBCL (P = .02). Epstein-Barr virus (EBV) expression was seen in 10 of 15 cases, and in those with HRS-L cells, EBV expression was detected invariably in at least a subset of the HRS-L cells. MYC gene rearrangements were consistently absent, although 6 of the 10 cases showed MYC overexpression by immunohistochemistry in the neoplastic B cells; a frequency significantly increased compared to other cases of DLBCL not associated with a T-cell lymphoma: 29 of 166 (P = .005). In addition, when MYC was overexpressed in DLBCL, it was also weakly present in the HRS-L cells. The increased and frequent morphologic presence of HRS-L cells in association with this composite lymphoma r...Continue Reading

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Citations

Mar 18, 2017·Current Oncology Reports·Rosalind F SandellAndrew L Feldman
Feb 8, 2019·Cytometry. Part B, Clinical Cytometry·Dragan Jevremovic, Horatiu Olteanu
Apr 7, 2020·Nature Reviews. Cancer·Danilo FioreGiorgio Inghirami
Jun 6, 2020·Molecular and Clinical Oncology·Diwash JangamRobert Shigeo Ohgami
May 1, 2021·Frontiers in Oncology·Valentina FragliassoAlessia Ciarrocchi
Jun 13, 2021·American Journal of Clinical Pathology·Yi Xie, Elaine S Jaffe

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