PMID: 7540441Mar 1, 1995Paper

An analysis of platelet activation and aggregation produced by three classes of contrast media

Journal of Vascular and Interventional Radiology : JVIR
K L Hay, B S Bull

Abstract

To evaluate the platelet activation and aggregation produced by ionic high-osmolality contrast media (HOCM) and both ionic and nonionic low-osmolality contrast media (LOCM). After each agent was mixed with heparinized blood, sequential platelet counts were used to monitor platelet aggregation, and flow cytometry was used to monitor both aggregation and activation. Aggregation was measured with CD41a-FITC (specific for glycoprotein IIb-IIIa) and activation was measured with CD62-PE (specific for P-selectin). High concentrations of the nonionic LOCM (> 31% by volume in whole blood) induced more than 90% platelet activation within 2 minutes of exposure to freshly drawn heparinized whole blood. Aggregation followed immediately after activation and was somewhat reversible. High concentrations of the ionic HOCM (> 31%) induced prominent activation, although it occurred at a much slower rate and to a lesser degree than with the nonionic media. There was approximately 70% activation after 45 minutes of exposure. Ionic HOCM inhibited platelet aggregation, however. The ionic LOCM ioxaglate produced minimal or no platelet aggregation or activation. There is likely to be an agent-related difference in the risk of platelet activation and ag...Continue Reading

Citations

May 1, 1997·Investigative Radiology·W Krause, W R Press
Jan 8, 2016·The American Journal of Cardiology·Gaetano Antonio LanzaFilippo Crea
May 1, 1996·Academic Radiology·L G MeltonD A Gabriel
May 1, 1996·Journal of Vascular and Interventional Radiology : JVIR·K L Hay, B S Bull

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.