May 1, 1977

An analysis of the characteristics of the adrenergic neurone blocking action of dimethylphenylpiperazinium

Archives Internationales De Pharmacodynamie Et De Thérapie
S Jayasundar, M M Vohra


An analysis of the characteristics of the adrenergic neurone blocking action of 1,1-dimethyl-4-phenylpiperazinium (DMPP) was undertaken using rat isolated vasa deferentia. DMPP (1 X 10(-6) to 1.5 X 10(-5) g/ml) reduced progressively the contractile response to transmural stimulation (TMS) in a dose-dependent manner without inhibiting the response to exogenous norepinephrine. The DMPP-induced inhibition was not reversed by washing but could be antagonized by dexamphetamine in a concentration which did not by itself affect the response to TMS. Among other sympathomimetic amines tested, it was seen that methamphetamine, ephedrine, phenylpropranolamine and mephentermine were effective in antagonizing DMPP-induce inhibition. High calcium (5 mM) reversed but did not prevent the DMPP-induced inhibition. DMPP reduced preferentially responses to high frequencies of stimulation without affecting those to low.

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Mentioned in this Paper

Depression, Chemical
Sympathetic Nervous System
Smooth Muscle
Drug Interactions
Dimethylphenylpiperazinium Iodide

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